Development of the novel method for the early diagnosis of Alzheimer's disease using high-resolution diffusion tensor imaging at 7 Tesla MRI

• Project/Area Number: 25861119
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: Ito Kenji 岩手医科大学, 医学部, 助教 (80646852)
• Research Collaborator: SASAKI Makoto ; TERAYAMA Yasuo
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 拡散MRI / 軽度認知障害 / アルツハイマー病 / パーキンソン症候群 / 早期鑑別診断 / 認知症 / 海馬傍回帯状束 / 後部帯状束 / 拡散テンソル

Outline of Final Research Achievements

High-resolution 3-Tesla diffusion tensor imaging analysis was able to detect substantial changes in diffusion anisotropy and diffusivity in the parahippocampal cingulum bundle of patients with mid cognitive impairment (MCI) who were destined to convert to Alzheimer’s disease (AD). Our method may prove effective for the early diagnosis of patients with MCI who will eventually convert to AD. Moreover, we developed high-resolution 7-Tesla diffusion tensor imaging based on the reduced field of view. The combination of our method and the multiband acceleration in the slice direction can be used to establish the innovative imaging technique for the early diagnosis of patients with MCI.

Research Products

• [Journal Article] Optimization of Scan Parameters to Reduce Acquisition Time for Diffusion Kurtosis Imaging at 1.5T (2016)
  • Author(s): Yokosawa S, Sasaki M, Bito Y, Ito K, Yamashita F, Goodwin J, Higuchi S, Kudo K
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 15 Issue: 1 Pages: 41-48
  • DOI: 10.2463/mrms.2014-0139
  • NAID: 130005118980
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings (2016)
  • Author(s): Ito K, Kudo M, Sasaki M, Saito A, Yamashita F, Harada T, Yokosawa S, Uwano I, Kameda H, Terayama Y
  • Journal Title: Neuroradiology Volume: 58(2) Issue: 2 Pages: 115-120
  • DOI: 10.1007/s00234-015-1603-8
  • Peer Reviewed
• [Journal Article] Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1weighted imaging (2015)
  • Author(s): Takahashi, J., Shibata, T., Sasaki, M., Kudo, M., Yanezawa, H., Obara, S., Kudo, K., Ito, K., Yamashita, F. and Terayama, Y.
  • Journal Title: Geriatrics & Gerontology International Volume: 15 Issue: 3 Pages: 334-340
  • DOI: 10.1111/ggi.12280
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Sensations Experienced by Subjects during MR Imaging Examination at 7T (2015)
  • Author(s): Uwano I, Metoki T, Sendai F, Yoshida R, Kudo K, Yamashita F, Higuchi S, Ito K, Harada T, Goodwin J, Ogawa A, Sasaki M
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 1 Pages: 35-41
  • DOI: 10.2463/mrms.2014-0004
  • NAID: 130004700395
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Detection of early changes in the parahippocampal and posterior cingulum bundles during mild cognitive impairment by using high-resolution multi-parametric diffusion tensor imaging (2015)
  • Author(s): Ito, K., Sasaki, MM., Takahashi, J., Uwano, I., Yamashita, F., Higuchi, S., Goodwin, J., Harada, T., Kudo, K. and Terayama, Y.
  • Journal Title: Psychiatry Rresearch: Neuroimaging Volume: 231 Issue: 3 Pages: 346-352
  • DOI: 10.1016/j.pscychresns.2015.01.020
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation among parkinsonisms using quantitative diffusion kurtosis imaging (2015)
  • Author(s): Ito K, Sasaki M, Ohtsuka C, Yokosawa S, Harada T, Uwano I, Yamashita F, Higuchi S, Terayama Y
  • Journal Title: Neuroreport Volume: 26(5) Issue: 5 Pages: 267-272
  • DOI: 10.1097/wnr.0000000000000341
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluating Middle Cerebral Artery Atherosclerotic Lesions in Acute Ischemic Stroke Using Magnetic Resonance T1-Weighted 3-Dimensional Vessel Wall Imaging (2014)
  • Author(s): Natori T, Sasaki M, Miyoshi M, Ohba H, Katsura N, Yamaguchi M, Narumi S, Kabasawa H, Kudo K, Ito K, Terayama Y
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 23 Issue: 4 Pages: 706-711
  • DOI: 10.1016/j.jstrokecerebrovasdis.2013.06.025
  • Peer Reviewed
• [Journal Article] Voxel-based morphometry of disproportionate cerebrospinal fluid space distribution for the differential diagnosis of idiopathic normal pressure hydrocephalus. (2014)
  • Author(s): Yamashita F, Sasaki M, Saito M, Mori E, Kawaguchi A, Kudo K, Natori T, Uwano I, Ito K, Saito K.
  • Journal Title: J Neuroimaging Volume: 24 Issue: 4 Pages: 359-365
  • DOI: 10.1111/jon.12049
  • Peer Reviewed
• [Journal Article] Intensity inhomogeneity correction for magnetic resonance imaging of human brain at 7T (2014)
  • Author(s): Uwano I, Kudo K, Yamashita F, Goodwin J, Higuchi S, Ito K, Harada T, Ogawa A, Sasaki M
  • Journal Title: Med Phys Volume: 41(2) Issue: 2 Pages: 22302-22302
  • DOI: 10.1118/1.4860954
  • Peer Reviewed
• [Journal Article] Noninvasive evaluation of collateral blood flow through circle of willis in cervical carotid stenosis using selective Magnetic Resonance Angiography (2013)
  • Author(s): Ito K, Sasaki M, Kobayashi M, Ogasawara K, Nishihara T, Takahashi T, Natori T, Uwano I, Yamashita F, Kudo K
  • Journal Title: J Stroke Cerebrovasc Dis. 2013 Oct 5. pii: S1052-3057(13)00347-9. Volume: 13 Issue: 5 Pages: 347-9
  • DOI: 10.1016/j.jstrokecerebrovasdis.2013.08.018
  • Peer Reviewed / Open Access
• [Presentation] Differentiation of Early-Stage Parkinsonisms with Diffusion Kurtosis Imaging Using The Diffusion Magnetic Resonance Parkinsonism Index (2015)
  • Author(s): Ito K, Sasaki M, Ohtsuka C, Yokosawa S, Harada T, Uwano I, Yamashita F, Higuchi S, Terayama Y
  • Organizer: 23rd Annual Meeting ISMRM
  • Place of Presentation: Toronto (Canada)
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Measurement of the Oxygen Extraction Fraction in Patients with Steno-occlusive Cerebrovascular Diseases using Quantitative Susceptibility Mapping at 7 (2015)
  • Author(s): Uwano I, Sasaki M, Kudo K, Sato R, Ogasawara Y, Saura H, Ogasawara K, Harada T, Ito K, Yamashita F, Higuchi S, Goodwin J, Higuchi S
  • Organizer: 23rd Annual Meeting ISMRM
  • Place of Presentation: Toronto (Canada)
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Differentiation of Early Parkinsonism with DKI using the Diffusion MRPI (2015)
  • Author(s): 大塚千久美，佐々木真理，伊藤賢司，紺野可奈子，加藤可奈子，寺山靖夫
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] 拡散尖度画像を用いた片頭痛患者における中脳水道周囲灰白質の評価 (2015)
  • Author(s): 伊藤賢司, 佐々木真理, 工藤雅子, 齋藤あゆみ, 横沢俊, 原田太以佑, 上野育子, 山下典生, 樋口さとみ, 寺山靖夫
  • Organizer: 第44回日本神経放射線学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-06 – 2015-03-07
• [Presentation] 拡散尖度画像と定量的磁化率画像を用いたパーキンソン症候群の早期鑑別診断 (2014)
  • Author(s): 伊藤賢司, 佐々木真理, 大塚千久美, 横沢俊, 佐藤良太, 尾藤良孝, 原田太以佑, 上野育子, 山下典生, 樋口さとみ, Jonathan Goodwin, 寺山靖夫
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] Differentiation of early-stage Parkinsonisms using diffusion kurtosis/tensor imaging (2014)
  • Author(s): Ito K, Sasaki M, Ohtsuka C, Uwano I, Yamashita F, Higuchi S, Goodwin J, Harada T, Terayama Y
  • Organizer: 22nd ISMRM
  • Place of Presentation: Milano (Italy)
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] 拡散尖度画像を用いたパーキンソン症候群の早期鑑別診断 (2014)
  • Author(s): 伊藤賢司、佐々木真理、大塚千久美、横沢俊、尾藤良孝、上野育子、山下典生、樋口 さとみ、Jonathan Goodwin、原田太以佑、寺山靖夫
  • Organizer: 第43回日本神経放射線学会
  • Place of Presentation: 鳥取
• [Presentation] Differentiation of Early-Stage Parkinsonisms using Diffusion Kurtosis/Tensor Imaging (2014)
  • Author(s): Kenji Ito, Makoto Sasaki, Chigumi Ohtuka, Ikuko Uwano, Fumio Yamashita, Satomi Higuchi, Jonathan Goodwin, Taisuke Harada, Yasuo Terayama
  • Organizer: 22nd ISMRM2014
  • Place of Presentation: Milano(Italia)
• [Presentation] 軽度認知障害とアルツハイマー病における海馬傍回帯状束の変化：高解像度拡散テンソル画像による検討 (2013)
  • Author(s): 伊藤賢司、佐々木真理、高橋純子、山下典生、樋口さとみ、Jonathan Goodwin 、上野育子、原田太以佑
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島
• [Presentation] High-resolution diffusion tensor imaging of the parahippocampal cingulum and posterior cingulum bundles in patients with mild cognitive impairment and Alzheimer’s disease (2013)
  • Author(s): Kenji Ito, Makoto Sasaki, Junko Takahashi, Fumio Yamashita, Satomi Higuchi, Jonathan Goodwin, Ikuko Uwano, Taisuke Harada
  • Organizer: 99th RSNA2013
  • Place of Presentation: Chicago(USA)