• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the novel method for the early diagnosis of Alzheimer's disease using high-resolution diffusion tensor imaging at 7 Tesla MRI

Research Project

Project/Area Number 25861119
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

Ito Kenji  岩手医科大学, 医学部, 助教 (80646852)

Research Collaborator SASAKI Makoto  
TERAYAMA Yasuo  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords拡散MRI / 軽度認知障害 / アルツハイマー病 / パーキンソン症候群 / 早期鑑別診断 / 認知症 / 海馬傍回帯状束 / 後部帯状束 / 拡散テンソル
Outline of Final Research Achievements

High-resolution 3-Tesla diffusion tensor imaging analysis was able to detect substantial changes in diffusion anisotropy and diffusivity in the parahippocampal cingulum bundle of patients with mid cognitive impairment (MCI) who were destined to convert to Alzheimer’s disease (AD). Our method may prove effective for the early diagnosis of patients with MCI who will eventually convert to AD. Moreover, we developed high-resolution 7-Tesla diffusion tensor imaging based on the reduced field of view. The combination of our method and the multiband acceleration in the slice direction can be used to establish the innovative imaging technique for the early diagnosis of patients with MCI.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Optimization of Scan Parameters to Reduce Acquisition Time for Diffusion Kurtosis Imaging at 1.5T2016

    • Author(s)
      Yokosawa S, Sasaki M, Bito Y, Ito K, Yamashita F, Goodwin J, Higuchi S, Kudo K
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 15 Issue: 1 Pages: 41-48

    • DOI

      10.2463/mrms.2014-0139

    • NAID

      130005118980

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings2016

    • Author(s)
      Ito K, Kudo M, Sasaki M, Saito A, Yamashita F, Harada T, Yokosawa S, Uwano I, Kameda H, Terayama Y
    • Journal Title

      Neuroradiology

      Volume: 58(2) Issue: 2 Pages: 115-120

    • DOI

      10.1007/s00234-015-1603-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1weighted imaging2015

    • Author(s)
      Takahashi, J., Shibata, T., Sasaki, M., Kudo, M., Yanezawa, H., Obara, S., Kudo, K., Ito, K., Yamashita, F. and Terayama, Y.
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 15 Issue: 3 Pages: 334-340

    • DOI

      10.1111/ggi.12280

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of Sensations Experienced by Subjects during MR Imaging Examination at 7T2015

    • Author(s)
      Uwano I, Metoki T, Sendai F, Yoshida R, Kudo K, Yamashita F, Higuchi S, Ito K, Harada T, Goodwin J, Ogawa A, Sasaki M
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 14 Issue: 1 Pages: 35-41

    • DOI

      10.2463/mrms.2014-0004

    • NAID

      130004700395

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of early changes in the parahippocampal and posterior cingulum bundles during mild cognitive impairment by using high-resolution multi-parametric diffusion tensor imaging2015

    • Author(s)
      Ito, K., Sasaki, MM., Takahashi, J., Uwano, I., Yamashita, F., Higuchi, S., Goodwin, J., Harada, T., Kudo, K. and Terayama, Y.
    • Journal Title

      Psychiatry Rresearch: Neuroimaging

      Volume: 231 Issue: 3 Pages: 346-352

    • DOI

      10.1016/j.pscychresns.2015.01.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation among parkinsonisms using quantitative diffusion kurtosis imaging2015

    • Author(s)
      Ito K, Sasaki M, Ohtsuka C, Yokosawa S, Harada T, Uwano I, Yamashita F, Higuchi S, Terayama Y
    • Journal Title

      Neuroreport

      Volume: 26(5) Issue: 5 Pages: 267-272

    • DOI

      10.1097/wnr.0000000000000341

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluating Middle Cerebral Artery Atherosclerotic Lesions in Acute Ischemic Stroke Using Magnetic Resonance T1-Weighted 3-Dimensional Vessel Wall Imaging2014

    • Author(s)
      Natori T, Sasaki M, Miyoshi M, Ohba H, Katsura N, Yamaguchi M, Narumi S, Kabasawa H, Kudo K, Ito K, Terayama Y
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 23 Issue: 4 Pages: 706-711

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.06.025

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Voxel-based morphometry of disproportionate cerebrospinal fluid space distribution for the differential diagnosis of idiopathic normal pressure hydrocephalus.2014

    • Author(s)
      Yamashita F, Sasaki M, Saito M, Mori E, Kawaguchi A, Kudo K, Natori T, Uwano I, Ito K, Saito K.
    • Journal Title

      J Neuroimaging

      Volume: 24 Issue: 4 Pages: 359-365

    • DOI

      10.1111/jon.12049

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intensity inhomogeneity correction for magnetic resonance imaging of human brain at 7T2014

    • Author(s)
      Uwano I, Kudo K, Yamashita F, Goodwin J, Higuchi S, Ito K, Harada T, Ogawa A, Sasaki M
    • Journal Title

      Med Phys

      Volume: 41(2) Issue: 2 Pages: 22302-22302

    • DOI

      10.1118/1.4860954

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive evaluation of collateral blood flow through circle of willis in cervical carotid stenosis using selective Magnetic Resonance Angiography2013

    • Author(s)
      Ito K, Sasaki M, Kobayashi M, Ogasawara K, Nishihara T, Takahashi T, Natori T, Uwano I, Yamashita F, Kudo K
    • Journal Title

      J Stroke Cerebrovasc Dis. 2013 Oct 5. pii: S1052-3057(13)00347-9.

      Volume: 13 Issue: 5 Pages: 347-9

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.08.018

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Differentiation of Early-Stage Parkinsonisms with Diffusion Kurtosis Imaging Using The Diffusion Magnetic Resonance Parkinsonism Index2015

    • Author(s)
      Ito K, Sasaki M, Ohtsuka C, Yokosawa S, Harada T, Uwano I, Yamashita F, Higuchi S, Terayama Y
    • Organizer
      23rd Annual Meeting ISMRM
    • Place of Presentation
      Toronto (Canada)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of the Oxygen Extraction Fraction in Patients with Steno-occlusive Cerebrovascular Diseases using Quantitative Susceptibility Mapping at 72015

    • Author(s)
      Uwano I, Sasaki M, Kudo K, Sato R, Ogasawara Y, Saura H, Ogasawara K, Harada T, Ito K, Yamashita F, Higuchi S, Goodwin J, Higuchi S
    • Organizer
      23rd Annual Meeting ISMRM
    • Place of Presentation
      Toronto (Canada)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differentiation of Early Parkinsonism with DKI using the Diffusion MRPI2015

    • Author(s)
      大塚千久美,佐々木真理,伊藤賢司,紺野可奈子,加藤可奈子,寺山靖夫
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 拡散尖度画像を用いた片頭痛患者における中脳水道周囲灰白質の評価2015

    • Author(s)
      伊藤賢司, 佐々木真理, 工藤雅子, 齋藤あゆみ, 横沢俊, 原田太以佑, 上野育子, 山下典生, 樋口さとみ, 寺山靖夫
    • Organizer
      第44回日本神経放射線学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 拡散尖度画像と定量的磁化率画像を用いたパーキンソン症候群の早期鑑別診断2014

    • Author(s)
      伊藤賢司, 佐々木真理, 大塚千久美, 横沢俊, 佐藤良太, 尾藤良孝, 原田太以佑, 上野育子, 山下典生, 樋口さとみ, Jonathan Goodwin, 寺山靖夫
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Differentiation of early-stage Parkinsonisms using diffusion kurtosis/tensor imaging2014

    • Author(s)
      Ito K, Sasaki M, Ohtsuka C, Uwano I, Yamashita F, Higuchi S, Goodwin J, Harada T, Terayama Y
    • Organizer
      22nd ISMRM
    • Place of Presentation
      Milano (Italy)
    • Year and Date
      2014-05-10 – 2014-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 拡散尖度画像を用いたパーキンソン症候群の早期鑑別診断2014

    • Author(s)
      伊藤賢司、佐々木真理、大塚千久美、横沢俊、尾藤良孝、上野育子、山下典生、樋口 さとみ、Jonathan Goodwin、原田太以佑、寺山靖夫
    • Organizer
      第43回日本神経放射線学会
    • Place of Presentation
      鳥取
    • Related Report
      2013 Research-status Report
  • [Presentation] Differentiation of Early-Stage Parkinsonisms using Diffusion Kurtosis/Tensor Imaging2014

    • Author(s)
      Kenji Ito, Makoto Sasaki, Chigumi Ohtuka, Ikuko Uwano, Fumio Yamashita, Satomi Higuchi, Jonathan Goodwin, Taisuke Harada, Yasuo Terayama
    • Organizer
      22nd ISMRM2014
    • Place of Presentation
      Milano(Italia)
    • Related Report
      2013 Research-status Report
  • [Presentation] 軽度認知障害とアルツハイマー病における海馬傍回帯状束の変化:高解像度拡散テンソル画像による検討2013

    • Author(s)
      伊藤賢司、佐々木真理、高橋純子、山下典生、樋口さとみ、Jonathan Goodwin 、上野育子、原田太以佑
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      徳島
    • Related Report
      2013 Research-status Report
  • [Presentation] High-resolution diffusion tensor imaging of the parahippocampal cingulum and posterior cingulum bundles in patients with mild cognitive impairment and Alzheimer’s disease2013

    • Author(s)
      Kenji Ito, Makoto Sasaki, Junko Takahashi, Fumio Yamashita, Satomi Higuchi, Jonathan Goodwin, Ikuko Uwano, Taisuke Harada
    • Organizer
      99th RSNA2013
    • Place of Presentation
      Chicago(USA)
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi