Biological optimization for brachytherapy combined with external beam radiation therapy

• Project/Area Number: 25861124
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: Shiraishi Yutaka 慶應義塾大学, 医学部, 講師 (00445339)
• Research Collaborator: YOROZU Atsunori ; OHASHI Toshio ; HANADA Takashi
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 小線源治療 / 外照射 / 最適化 / 放射線治療 / 有害事象低減

Outline of Final Research Achievements

We demonstrated generalized equivalent uniform doses (gEUD) to be a potential predictive factor for grade 2+ late rectal bleeding after I-125 prostate brachytherapy combined with external beam radiation therapy. We tested the NTCP model suggested by the QUANTEC review (quantitative analysis of normal tissue effects in the clinic) of late rectal bleeding dose-volume factors: the Lyman-Kutcher-Burman (LKB) model, using gEUD. This study calculated NTCP parameter values for late rectal bleeding observed in combined therapy.

Research Products

• [Journal Article] A dose-response analysis of biochemical control outcomes after (125)I monotherapy for patients with favorable-risk prostate cancer. (2014)
  • Author(s): Shiraishi Y, Yorozu A, Ohashi T, Toya K, Saito S, Nishiyama T, Yagi Y, Shigematsu N
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 90（５） Issue: 5 Pages: 1069-75
  • DOI: 10.1016/j.ijrobp.2014.08.340
  • Peer Reviewed
• [Journal Article] Novel parameter predicting grade 2 rectal bleeding after iodine-125 prostate brachytherapy combined with external beam radiation therapy (2013)
  • Author(s): Shiraishi Y, Hanada T, Ohashi T, Yorozu A, Toya K, Saito S, Shigematsu N
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 87 Issue: 1 Pages: 182-7
  • DOI: 10.1016/j.ijrobp.2013.04.047
  • Peer Reviewed
• [Presentation] Normal Tissue Complication Probability (NTCP) Modeling of Late Rectal Bleeding Following Iodine-125 Prostate Brachytherapy Combined With External Beam Radiation Therapy (2015)
  • Author(s): Y. Shiraishi, T. Hanada, T. Ohashi, A. Yorozu, N. Shigematsu
  • Organizer: ASTRO 57th Anｎual Meeting
  • Place of Presentation: サンアントニオ（アメリカ合衆国）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Transperineal Mapping Biopsy Results following Continuous PSA Rises in Patients Treated with Iodine-125 Prostate Brachytherapy (2015)
  • Author(s): Yutaka Shiraishi, Atsunori Yorozu, Shiro Saito, Toru Nishiyama, Yasuto Yagi, Akane Takahashi, Nobuko Kuroiwa, Takahisa Eriguchi, Kazuhito Toya, Toshio Ohashi, Naoyuki Shigematsu
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2015-05-25 – 2015-05-29
• [Presentation] Transperineal Mapping Biopsy Results following Continuous PSA Rises in Patients Treated with Iodine-125 Prostate Brachytherapy (2015)
  • Author(s): Y. Shiraishi, A. Yorozu, S. Saito, T. Nishiyama, Y. Yagi, A. Takahashi, N. Kuroiwa, T. Eriguchi, K. Toya, T. Ohashi, N. Shigematsu
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 国立京都国際会館（京都府京都市左京区）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Prostate Postimplant CT With Metal Artifacts Reduction for Improvement of Seed Localization (2014)
  • Author(s): Y. Shiraishi, Y. Yamada, T. Ohashi, T. Hanada, M. Jinzaki, S. Kuribayashi, N. Shigematsu
  • Organizer: ASTRO 56th annual meeting
  • Place of Presentation: サンフランシスコ（アメリカ合衆国）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] A Novel Parameter Predicting Grade 2 Rectal Bleeding After I-125 Prostate Brachytherapy Combined With External Beam Radiation Therapy (2013)
  • Author(s): Y. Shiraishi, T. Hanada, T. Ohashi, A. Yorozu, K. Toya, N. Shigematsu
  • Organizer: ASTRO 55th annual meeting
  • Place of Presentation: アトランタ（アメリカ合衆国）
• [Presentation] 外照射併用前立腺癌シード治療後の直腸出血を予測する新たな線量指標 (2013)
  • Author(s): 白石悠、花田剛士、大橋俊夫、萬篤憲、戸矢和仁、関智史、深田淳一、茂松直之
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森市文化会館（青森県）