Pravastatin reduces radiation-induced damage to normal tissues

• Project/Area Number: 25861134
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hyogo Medical University
• Principal Investigator: Doi Hiroshi 兵庫医科大学, 医学部, 助教 (50529047)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 放射線防護剤 / 放射線治療 / 放射線防護 / 放射線増感 / 放射線腸炎 / 放射線肺臓炎 / スタチン / プラバスタチン / 前立腺癌 / 放射線増感剤 / 肥満

Outline of Final Research Achievements

The purpose of this study was to assess the radioprotective effects of pravastatin in an experimental animal model. Mice were divided into two groups: the control group received ionizing radiation (IR) without medication and the pravastatin group received pravastatin prior to IR. Intestinal crypt epithelial cell survival and the incidence of apoptosis in the intestine and lung were measured post-IR. The effect of pravastatin on intestinal DNA damage was determined by immunohistochemistry. Pravastatin increased the number of viable intestinal crypts and this effect was statistically significant in the ileum. The pravastatin group showed significantly lower apoptotic indices in all examined parts of the intestine and tended to show reduced apoptosis in the lung. Pravastatin reduced the intestinal expression of gamma-H2AX and ataxia telangiectasia mutated after IR. To conclude, pravastatin had radioprotective effects on the normal tissues.

Research Products

• [Journal Article] Pravastatin reduces radiation-induced damage to normal tissues (2016)
  • Author(s): Doi H, Matsumoto S, Odawara S, Shikata T, Tanooka M, Kosaka K, Kitajima K, Takada Y, Tsujimura T, Kamikonya N, Hirota S
  • Journal Title: Experimental and Therapeutic Medicine Volume: 未定
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer (2016)
  • Author(s): Doi H, Kitajima K, Fukushima K, Kawanaka Y, Mouri M, Yamamoto S, Ishikura R, Terada T, Noguchi K, Hirota S.
  • Journal Title: Japan Journal of Radiology Volume: 34 Issue: 5 Pages: 349-355
  • DOI: 10.1007/s11604-016-0531-9
  • NAID: 50009841911
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Body mass index can affect gastrointestinal and genitourinary toxicity in patients with prostate cancer treated with external beam radiation therapy (2014)
  • Author(s): HIROSHI DOI, FUMIKO ISHIMARU, MASAO TANOOKA, HIROYUKI INOUE, SOICHI ODAWARA, YASUHIRO TAKADA, YASUE NIWA, MASAYUKI FUJIWARA, NORIHIKO KAMIKONYA, SHINGO YAMAMOTO, SHOZO HIROTA
  • Journal Title: Oncology Letters Volume: 7(1) Issue: 1 Pages: 209-214
  • DOI: 10.3892/ol.2013.1658
  • Peer Reviewed
• [Presentation] Pravastatin reduces radiation-induced injury with suppression of DNA double-strand breaks (2016)
  • Author(s): Doi H, Matsumoto S, Odawara S, Shikata T, Kitajima K, Tanooka M, Takada Y, Tsujimura T, Kamikonya N, Hirota S
  • Organizer: 4th International Symposium of training plan for oncology professionals
  • Place of Presentation: シェラトン都ホテル大阪、大阪
  • Year and Date: 2016-02-25
• [Presentation] Pravastatin protects normal intestine and lung from radiation exposure in mice (2015)
  • Author(s): 土井啓至，松本成司、小田原聡一，志方敏幸，田ノ岡征雄，小坂賢吾，北島一宏，髙田康弘，辻村亨，上紺屋憲彦，廣田省三
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: 前橋商工会議所会館、前橋、群馬
  • Year and Date: 2015-11-19
• [Presentation] Pravastatin protects normal intestinal epithelium and normal lung from radiation-induced cell death (2015)
  • Author(s): Doi H,Odawara S, Matsumoto S, Shikata T, Suzuki H, Kato T, Tarutani K, Kosaka K, Inoue H, Tanooka M, Takada Y, Tsujimura T, Kamikonya N, Hirota S
  • Organizer: The European Cancer Congress 2015
  • Place of Presentation: Messe Wien Exhibition & Congress Center, Vienna,Austria
  • Year and Date: 2015-09-25
  • Int'l Joint Research