Phosphatome-constitution predisposed to breast cancer

• Project/Area Number: 25861168
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: FUKAMACHI KAYOKO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (00626137)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 乳がん / HER2 / ホスファターゼ / BRCA1 / PP6 / SNPs / ノックアウトマウス / 発がん実験 / HER２ / BRCA１ / PP６

Outline of Final Research Achievements

Dysregulation of HER2 and BRCA1 phosphorylation are thought to be causes of mammary carcinogenesis. As PP6, one of protein phosphatase, was thought function in this process, we analyzed role of PP6 in carcinogenesis in mice. We found that abrogation of PP6 promotes skin carcinogenesis induced by DMBA.

Research Products

• [Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA (2015)
  • Author(s): Hayashi K, Momoi Y , Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, and Shima H
  • Journal Title: Oncogene Volume: 印刷中 Issue: 35 Pages: 4647-55
  • DOI: 10.1038/onc.2014.398
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cigarette smoking and breast cancer risk in relation to joint estrogen and progesterone receptor status: a case-control study in Japan (2014)
  • Author(s): Yoshikazu Nishino, Yuko Minami, Masaaki Kawai, Kayoko Fukamachi, Ikuro Sato, Noriaki Ohuchi, Yoichiro Kakugawa
  • Journal Title: Springerplus Volume: 3;65 Issue: 1 Pages: 1-15
  • DOI: 10.1186/2193-1801-3-65
  • Peer Reviewed