The role of CGRP in regulation of colonic motility and defecation

• Project/Area Number: 25861170
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: Nagao Munenori 東北大学, 大学病院, 助教 (60451564)
• Research Collaborator: ONO Tomoyuki ; SHIBUYA Emiko
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: GMC / CGRP / 排便

Outline of Final Research Achievements

We measured colonic motility to analyze the effect of intravenous administration of CGRP(calcitonin gene-related peptide) in conscious dogs. Intravenous administration of CGRP induced giant migrating contraction and defecation in colon. The frequency of the contractions increased dose-dependently. The results suggest that intravenous administration of CGRP may induce the colonic motility and defecation. Besides, the result may contribute to the development of the new laxative which has less side effects and can be administered intravenously.