| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Homeobox B9 (HoxB9), a transcriptional factor, regulates developmental processes and tumor progression and has recently been recognized as one of important transcriptional factors related to angiogenesis. The purpose of this study is elucidate whether HoxB9 affects tumor angiogenesis and therapeutic response to Sorafenib in HCC. HoxB9 was highly expressed in 29 of 79 (37%) patients. HOXB9 induced angiogenesis and tumor proliferation in vitro, which resulted in poor overall survival. Sorafenib remarkably suppressed tumor proliferation by inhibiting angiogenesis and Raf/ERK pathway in HOXB9-overexpressing cells, and it improved overall survival in HOXB9-overexpressing patients. HOXB9 overexpression in clinical specimens was significantly correlated with increased several angiogenic factors and Raf/ERK pathway.
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