Morphological and functional changes in the interstitial cells of Cajal in adenoma regions of the small intestine.
| Project/Area Number |
25861219
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
Kikuta Sachiko 東京女子医科大学, 医学部, 助教 (10367089)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | カハールの介在細胞 / 消化管 / APCMin/+ / カハールの介在細胞（ICC） / APCMin/+マウス / ApcMin/+マウス / カハールの介在細胞（ICC) / 免疫組織化学 |
|---|
| Outline of Final Research Achievements |
The present study has been designed to clarify the morphological changes in tunica muscularis in adenoma regions, with special reference to interstitial cells of Cajal (ICC). We noted that the thickening of tunica muscularis and the increase of ICC occurred in adenoma regions of ApcMin/+ mice. ICC act as both pacemakers and intermediates between nerves and smooth muscle cells.
In the adenoma region, the increase in the mass of intercellular substances caused thickening of the tunica muscularis, resulting in the loss of attachments among smooth muscle cells. The proliferation of ICC was involved in a dense distribution of ICC associated with the myenteric plexus (ICC-MP). Cytoplasmic processes of ICC-MP elongated into circular and longitudinal muscle layers. These processes were closely associated with the nerves and showed the gap-junction protein expression. These results may suggest that ICC compensate the lack of connections among smooth muscle cells with their mediator function.
|
Report
(5 results)
Research Products
(5 results)
