| Project/Area Number |
25861226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HOSHI TOMOYA 筑波大学, 医学医療系, 講師 (30618533)
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| Co-Investigator(Renkei-kenkyūsha) |
TAJIRI Kazuko 筑波大学, 医学医療系, 助教 (60633914)
KIMURA Taizo 筑波大学, 附属病院, 病院講師 (00636508)
SATO Akira 筑波大学, 医学医療系, 准教授 (30528469)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 血管内膜治癒反応 / 冠動脈ステント / 薬剤溶出性ステント / 光干渉断層計 / 血管内膜修復反応 / OCT / 光干渉断層法 |
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| Outline of Final Research Achievements |
In rabbit model, we evaluated the vascular healing response at 1-month and 3-months after stent implantation by using optical coherence tomography (OCT) and quantitative real-time reverse-transcription polymerase chain reaction (QRT-PCR) analyses. OCT showed that everolimus-eluting stent (EES) and bare metal stent (BMS) had a more favorable stent-strut coverage than the silorimus-eluting stent (SES) at both 1-month and 3-months after the implantation. The SES showed significantly less neointimal thickening than the EES and BMS at 3-months. In the QRT-PCR analyses, at 1-month, the gene expression of the proteoglycans were more upregulated in the BMS than in the SES. However, at 3-months after stenting, the gene expression of proteoglycans and collagen was more upregulated in the SES than in the EES and BMS. Compared to the EES, the vascular healing-related gene expression was rather upregulated in SES at 3-months, representing an ongoing active vascular healing process.
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