Establishment of novel lung SCC model using deltaNp63 inducible system
| Project/Area Number |
25861248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
YAMANO Shotaro 大阪市立大学, 医学(系)研究科(研究院), 助教 (80614528)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | deltaNp63 / TET/On / lung / TET/on |
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| Outline of Final Research Achievements |
【Objective】In this study, we challenged the establishment of novel mice model of lung Squamous cell carcinoma (SCC) using lung epithelium specific deltaNp63 inducible system and evaluated the role of deltaNp63 positive cancer cells in the lung SCC of the peripheral type. 【Results】We could not succeed the establishment of novel mice model of lung SCC. Nevertheless, we clearly observed that deltaNp63 positive cancer cells were co-expressed CD44v, Ki67 and P-Stat3 proteins and tumor associated macrophages (TAMs) were increasing near these cells. These data indicated that TAMs might be needed for deltaNp63 positive cancer cells monoclonal expansions and the formation of the tumor microenvironment in lung SCC.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Clinicopathological significance of combined analysis of cytokeratin19 expression and preoperative serum CYFRA21-1 levels in human lung squamous cell carcinoma.2013
Author(s)
Hanada S, Nishiyama N, Mizuguchi S, Yamano S, Kakehashi A, Wei M, Inoue H, Komatsu H, Chung K, Suehiro S, Wanibuchi H.
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Journal Title
Osaka City Med J
Volume: 59
Pages: 35-44
NAID
Related Report
Peer Reviewed
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[Journal Article] Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors.2013
Author(s)
Komatsu H, Kakehashi A, Nishiyama N, Izumi N, Mizuguchi S, Yamano S, Inoue H, Hanada S, Chung K, Wei M, Suehiro S, Wanibuchi H.
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Journal Title
Cancer Biomark
Volume: 13
Pages: 171-180
Related Report
Peer Reviewed
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[Journal Article] Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.2013
Author(s)
Wei M, Yamada T, Yamano S, Kato M, Kakehashi A, Fujioka M, Tago Y, Kitano M, Wanibuchi H.
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Journal Title
Toxicol Appl Pharmacol
Volume: 253
Pages: 1-9
Related Report
Peer Reviewed
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