The effect of Vitamin D3 on the degradation of articular cartilage

• Project/Area Number: 25861336
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: OHTA Yoichi 大阪市立大学, 医学(系)研究科(研究院), 病院講師 (50633484)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 活性型ビタミンD3 / 関節軟骨 / 関節軟骨変性

Outline of Final Research Achievements

The purpose of this study was to investigate the effect of Vitamin D3 on the differentiation of chondrocytes and the degradation of articular cartilage. Primary mouse epiphyseal chondrocytes were isolated from new born mice, and subjected to gene expression analysis. Treatment with Vitamin D analog tended to stimulate Erg and lubricin (Prg4) expression. Local administration of Vitamin D analog to mice subjected to osteoarthritis (OA)-inducing surgery tended to decrease joint degradation following OA inducing surgery.

Research Products

• [Journal Article] In vivo wear particles of remelted highly crosslinked polyethylene after total hip arthroplasty: report of four cases. (2015)
  • Author(s): Hata K, Minoda Y, Ikebuchi M, Mizokawa S, Ohta Y, Miyazaki N, Miyake Y, Nakamura H.
  • Journal Title: Journal of Materials Science.Materials in Medicine. Volume: 26 Pages: 133-133
  • Peer Reviewed
• [Journal Article] Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice. (2013)
  • Author(s): Cantley L, Saunders C, Guttenberg M, Ohta Y, Yasuhara R, Kondo N, Tung W, Candela E. M, Sgariglia F, Asai S, Zhang X, Qin L, Hecht T. J, Chen D, Toyosawa S, Dormans P. J, Iwamoto M, Pacifici M and Enomoto-Iwamoto M.
  • Journal Title: Am J Pathol. Volume: 182(3) Issue: 3 Pages: 912-27
  • DOI: 10.1016/j.ajpath.2012.11.012
  • Peer Reviewed
• [Journal Article] Toward regeneration of articular cartilage. (2013)
  • Author(s): Iwamoto M, Ohta Y, Larmour C, Enomoto-Iwamoto M.
  • Journal Title: Birth Defects Res C Embryo Today. Volume: 99 Issue: 3 Pages: 192-202
  • DOI: 10.1002/bdrc.21042
  • Peer Reviewed
• [Presentation] Mobile-bearing TKA Reduced The Postoperative Anteroposterior Laxity Comparing To Fixed-bearing TKA In The Same Patients (2015)
  • Author(s): Minoda Y, Mizokawa S, Ohta Y, Ikebuchi M, Itokazu M, Yamamura K, Nakamura S, Nakamura H
  • Organizer: Annual meeting of Orthopaedic Research Society (ORS)
  • Place of Presentation: Las Vegas, Nevada (USA)
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] Peri-prosthetic Bone Mineral Density after Bilateral TKA: Mobile vs. Fixed Bearing prostheses (2015)
  • Author(s): Nakamura S, Minoda Y, Mizokawa S, Ohta Y, Itokazu M, Yamaura K, Nakamura H
  • Organizer: Annual meeting of Orthopaedic Research Society (ORS)
  • Place of Presentation: Las Vegas, Nevada (USA)
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] Assymentric Tibial Component Reduced The Risk Of Malrotation In TKA (2015)
  • Author(s): Minoda Y, Mizokawa S, Ohta Y, Itokazu M, Yamamura K, Nakamura S, Nakamura H.
  • Organizer: Annual meeting of American Academy of Orthopaedic Surgeons (AAOS)
  • Place of Presentation: Las Vegas, Nevada (USA)
  • Year and Date: 2015-03-24 – 2015-03-28
• [Presentation] Comparison Of In Vivo Polyethylene Wear Particles Between Mobile- And Fixed-bearing TKA In The Same Patients (2015)
  • Author(s): Minoda Y, Mizokawa S, Ohta Y, Ikebuchi M, Itokazu M, Yamaura K, Nakamura S, Nakamura H
  • Organizer: Annual meeting of American Academy of Orthopaedic Surgeons (AAOS)
  • Place of Presentation: Las Vegas, Nevada (USA)
  • Year and Date: 2015-03-24 – 2015-03-28
• [Presentation] 人工股関節置換術後におけるステム周囲の骨密度変化―Anatomical stemとZweymuller stemの術後4年の比較― (2014)
  • Author(s): 大田 陽一、箕田 行秀、溝川 滋一、糸数 万紀、山村 一正、渭川 徹秀、中村 博亮
  • Organizer: 第44回日本人工関節学会
  • Place of Presentation: 沖縄県宜野湾市／沖縄コンベンションセンター