The effect of Vitamin D3 on the degradation of articular cartilage
| Project/Area Number |
25861336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
OHTA Yoichi 大阪市立大学, 医学(系)研究科(研究院), 病院講師 (50633484)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 活性型ビタミンD3 / 関節軟骨 / 関節軟骨変性 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the effect of Vitamin D3 on the differentiation of chondrocytes and the degradation of articular cartilage. Primary mouse epiphyseal chondrocytes were isolated from new born mice, and subjected to gene expression analysis. Treatment with Vitamin D analog tended to stimulate Erg and lubricin (Prg4) expression. Local administration of Vitamin D analog to mice subjected to osteoarthritis (OA)-inducing surgery tended to decrease joint degradation following OA inducing surgery.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice.2013
Author(s)
Cantley L, Saunders C, Guttenberg M, Ohta Y, Yasuhara R, Kondo N, Tung W, Candela E. M, Sgariglia F, Asai S, Zhang X, Qin L, Hecht T. J, Chen D, Toyosawa S, Dormans P. J, Iwamoto M, Pacifici M and Enomoto-Iwamoto M.
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Journal Title
Am J Pathol.
Volume: 182(3)
Issue: 3
Pages: 912-27
DOI
Related Report
Peer Reviewed
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