Elucidation and control of the inhibitor to myocardium protection under depressive state

Research Project

Project/Area Number	25861380
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Nagasaki University
Principal Investigator	ICHINOMIYA Taiga 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50404249)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	薬理学的ポストコンディショニング / 虚血再灌流障害
Outline of Final Research Achievements	It is thought that PI3K-Akt activity without JAK-STAT is important for myocardial protection against ischemic reperfusion injury under depressive state. In this study, it was found that fasudil hydrochloride which is Rho kinase inhibitor activates m-KATP channel without JAK-STAT, COX-2 and showed myocardial protection. Therefore, fasudil hydrochloride may show myocardial protection under depressed state.

Report

(4 results)