Elucidation and control of the inhibitor to myocardium protection under depressive state
| Project/Area Number |
25861380
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
ICHINOMIYA Taiga 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50404249)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 薬理学的ポストコンディショニング / 虚血再灌流障害 |
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| Outline of Final Research Achievements |
It is thought that PI3K-Akt activity without JAK-STAT is important for myocardial protection against ischemic reperfusion injury under depressive state. In this study, it was found that fasudil hydrochloride which is Rho kinase inhibitor activates m-KATP channel without JAK-STAT, COX-2 and showed myocardial protection. Therefore, fasudil hydrochloride may show myocardial protection under depressed state.
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Report
(4 results)
Research Products
(3 results)
