Melatonin receptor agonist for the prevention of postoperative delirium

Research Project

Project/Area Number	25861391
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Yokohama City University
Principal Investigator	YAMAGUCHI Yoshikazu 横浜市立大学, 医学部, 助教 (50571212)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	せん妄 / メラトニン / 高齢者
Outline of Final Research Achievements	Melatonin is a hormone secreted by pineal gland. Melatonin regulates sleep-wake cycle and resets circadian rhythms. Ramelteon is the melatonin receptor 1 (MT1) agonist and used to sleep induction. The aim of our study was to evaluate whether the ramelteon could reduce the incidence of postoperative delirium and improve postoperative quality of recovery. Perioperative ramelteon showed the tendency to reduce the incidence of postoperative delirium, but not statistically significant. Further large randomized controlled trials are needed to assess ramelteon for the prevention of postoperative delirium in elderly patients during perioperative period.

Report

(4 results)