A study of the impact of chronic hypoxia has on the malignant transformation of prostate cancer cells

• Project/Area Number: 25861428
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Oita University
• Principal Investigator: YAMASAKI MUTSUSHI 大分大学, 医学部, 客員研究員 (90508863)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 低酸素 / 前立腺癌

Outline of Final Research Achievements

This study showed that chronic hypoxia environment plays an important role in malignant transformation of prostate cancer (androgen-independent behavior and enhancement of proliferation and invasion), and was elucidate that mechanism.
By analyzing the chronic hypoxia-conditioned prostate cancer cells, we indicated that the chronic hypoxia involved in enhancement of cell invasiveness, change of intracellular signaling and gene expression. We analyzed candidate genes involved in malignant potential of prostate cancer, and showed the potential for new therapies.

Research Products

• [Journal Article] Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells. (2015)
  • Author(s): Sato R, Yamasaki M, Hirai K, Matsubara T, Nomura T, Sato F, Mimata H
  • Journal Title: Oncol Rep. Volume: 33(1) Issue: 1 Pages: 58-66
  • DOI: 10.3892/or.2014.3586
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia. (2014)
  • Author(s): Hirai K, Nomura T, Yamasaki M, Inoue T, Narimatsu T, Chisato Nakada PD, Yoshiyuki Tsukamoto PD, Matsuura K, Sato F, Moriyama M, Mimata H
  • Journal Title: Urol Oncol Volume: 32(2) Issue: 2 Pages: 101-109
  • DOI: 10.1016/j.urolonc.2012.09.005
  • Peer Reviewed
• [Journal Article] Elucidating the molecular mechanism of prostate cancer progression under chronic hypoxia and development of the novel therapeutic approach (2014)
  • Author(s): Nomura T, Yamasaki M, Mimata H.
  • Journal Title: Nihon Rinsho. Volume: 72(12) Pages: 2136-2140
  • NAID: 40020270869
• [Journal Article] Chronic hypoxia induces androgen-independent and invasive behavior in LNCaP human prostate cancer cells. (2013)
  • Author(s): Yamasaki M, Nomura T, Sato F, Mimata H.
  • Journal Title: Urol Oncol. Volume: 31(7) Issue: 7 Pages: 1124-1131
  • DOI: 10.1016/j.urolonc.2011.12.007
  • Peer Reviewed
• [Journal Article] Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia. (2013)
  • Author(s): Nomura T, Yamasaki M, Hirai K, Inoue T, Sato R, Matsuura K, Moriyama M, Sato F, Mimata H.
  • Journal Title: Mol Cancer. Volume: 12 Issue: 1 Pages: 27-27
  • DOI: 10.1186/1476-4598-12-27
  • Peer Reviewed
• [Presentation] 前立腺癌におけるAngiopoietin-like protein 4発現の意義 (2015)
  • Author(s): 羽田真郎、佐藤竜太、山崎六志、野村威雄、佐藤文憲、三股浩光
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: 石川県立音楽堂他（石川県金沢市）
  • Year and Date: 2015-04-21
• [Presentation] 長期低酸素環境によって誘導される前立腺癌転移能獲得のメカニズムの解明 (2015)
  • Author(s): 岩崎和範、山崎六志、佐藤竜太、平井健一、住野泰弘、野村威雄、佐藤文憲、濱田文彦、三股浩光
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: 石川県立音楽堂他（石川県金沢市）
  • Year and Date: 2015-04-18