Grant-in-Aid for Young Scientists (B)
Ovarian cancer does occur at higher than expected rates in women with endometriosis. ARID1A and c-myc have high frequent mutations in ovarian clear cell carcinoma. The RNA editor gene ADAR1 is induced by inflammatory ligands and buffers stress response. The ADAR1 gene was overexpressed in endometriosis and ovarian clear cell carinoma cells.Exogenous ADAR1 induced adenosine-targeted DNA mutations in the ARID1A gene and the c-myc gene of wild-type mouse embryonic fibroblasts (MEFs) which have γ-H2AX expression.
Attribution of KAKENHI