Risk stratifications for oropharyngeal carcinoma in Japan

• Project/Area Number: 25861531
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: Saito Yuki 東京大学, 医学部附属病院, 助教 (40611009)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 中咽頭癌 / HPV / 頭頸部癌 / パピローマウィルス / リスク分類

Outline of Final Research Achievements

Over a 9-year period, a retrospective case comparison study of the pathology database was conducted. We performed immunohistochemistry for the p16 protein, in situ hybridization for human papillomavirus-deoxyribonucleic acid and polymerase chain reaction for the human papillomavirus-deoxyribonucleic acid oncogene E6 in oropharyngeal carcinoma in Japanese patients. In oropharyngeal carcinoma, the prevalences of p16(+)human papillomavirus(+), p16(+)human papillomavirus(-), p16(-)human papillomavirus(+) and p16(-)human papillomavirus(-) were 32% (48/150), 7% (10/150), 2% (3/150) and 59% (89/150), respectively.In multivariate Cox regression models, p16 was the independent prognostic factor, regardless of human papillomavirus status. The conclusion is p16 expression was a reliable prognostic and biomarker regardless of human papillomavirus status.

Research Products

• [Journal Article] Induction chemotherapy for p16 positive oropharyngeal squamous cell carcinoma. (2016)
  • Author(s): Yuki Saito, Mizuo Ando, Go Omura, Kazuo Yasuhara, Masafumi Yoshida, Wataru Takahashi, Tatsuya Yamasoba.
  • Journal Title: Laryngoscope Investigative Otolaryngology. Volume: in press Issue: 2 Pages: 28-32
  • DOI: 10.1002/lio2.18
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cerebral infarction after intra-arterial and intravenous chemoradiotherapy for head and neck cancer: a retrospective analysis using a Japanese inpatient database. (2016)
  • Author(s): Sayaka Suzuki, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yuki Saito, Tatsuya Yamasoba.
  • Journal Title: Head & Neck Volume: in press Issue: 9 Pages: 1354-1358
  • DOI: 10.1002/hed.24439
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Factors Associated With Neck Hematoma After Thyroidectomy: A Retrospective Analysis Using a Japanese Inpatient Database. (2016)
  • Author(s): Suzuki S, Yasunaga H, Matsui H, Fushimi K, Saito Y, Yamasoba T.
  • Journal Title: Medicine (Baltimore). Volume: 95 Issue: 7 Pages: e2812-e2812
  • DOI: 10.1097/md.0000000000002812
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human Papillomavirus 16 Physical Status and the TP53 Codon 72 Polymorphism in Japanese HPV-Positive Oropharyngeal Cancer Patients. (2016)
  • Author(s): Saito Y, Ando M, Fujimoto C, Omura G, Kobayashi K, Asakage T, Yamasoba T.
  • Journal Title: ORL J Otorhinolaryngol Relat Spec. Volume: 78(1) Issue: 1 Pages: 46-54
  • DOI: 10.1159/000442354
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in Postoperative Hearing Outcomes and Vertigo in Patients with Otosclerosis Treated with Laser-Assisted Stapedotomy versus Stapedectomy. (2015)
  • Author(s): Sakamoto T, Kikuta S, Kikkawa YS, Tsutsumiuchi K, Kanaya K, Fujimaki Y, Ueha R, Saito Y, Yamasoba T.
  • Journal Title: ORL J Otorhinolaryngol Relat Spec. Volume: 77 Issue: 5 Pages: 287-93
  • DOI: 10.1159/000439177
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic value of p16 expression irrespective of human papillomavirus status in patients with oropharyngeal carcinoma. (2015)
  • Author(s): Saito Y, Yoshida M, Omura G, Kobayashi K, Fujimoto C, Ando M, Sakamoto T, Asakage T, Yamasoba T.
  • Journal Title: Jpn J Clin Oncol. Volume: 45(9) Issue: 9 Pages: 828-836
  • DOI: 10.1093/jjco/hyv085
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nerve growth factor signal as possible pathogenic biomarkers for perineural invasion in adenoid cystic carcinoma. (2015)
  • Author(s): Kobayashi K, Ando M, Saito Y, Kondo K, Omura G, Ushiku A, Fukayama M, Asakage T, Yamasoba T
  • Journal Title: Otolaryngol Head Neck Surg Volume: 153 Issue: 2 Pages: 218-224
  • DOI: 10.1177/0194599815584762
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comorbidities Predict Poor Prognosis for Advanced Head and Neck Cancer Patients Treated with Major Surgery (2015)
  • Author(s): Go Omura, Yuki Saito, Mizuo Ando, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage
  • Journal Title: Head and Neck Volume: 未定 Issue: 3 Pages: 364-369
  • DOI: 10.1002/hed.23897
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Disease control and clinicopathological prognostic factors of total pharyngolaryngectomy for hypopharyngeal cancer: a single- center study (2015)
  • Author(s): Go Omura, Yuki Saito, Mizuo Ando, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage
  • Journal Title: International Journal of Clinical Oncology Volume: 20 Issue: 2 Pages: 290-297
  • DOI: 10.1007/s10147-014-0709-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Maxillary carcinosarcoma: Identification of a novel MET mutation in both carcinomatous and sarcomatous components through next generation sequencing (2015)
  • Author(s): Mizuo Ando, Yuki Saito, Teppei Morikawa, Go Omura, Kenya Kobayashi, Ken Akashi, Masafumi Yoshida, Yasuhiro Ebihara, Chisato Fujimoto, Masashi Fukayama, Tatsuya Yamasoba, Takahiro Asakage
  • Journal Title: Head and Neck Volume: 未定 Issue: 12
  • DOI: 10.1002/hed.24043
  • Peer Reviewed
• [Journal Article] Prognostic factors for long-term hearing preservation after canal-tympanoplasty for congenital aural atresia. (2015)
  • Author(s): Sakamoto T, Kikuta S, Kikkawa YS, Kinoshita M, Saito Y, Kobayashi K, Kakigi A, Suzuki M, Yamasoba T.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 272 Pages: 3151-6
  • Peer Reviewed
• [Journal Article] Clinical features of human papilloma virus-related head and neck squamous cell carcinoma of an unknown primary site. (2014)
  • Author(s): Kenya Kobayashi, Yuki Saito, Go Omura, Mizuo Ando, Takashi Sakamoto, Tatsuya Yamasoba, Takahiro Asakage
  • Journal Title: ORL Volume: 76 Issue: 3 Pages: 137-146
  • DOI: 10.1159/000363190
  • Peer Reviewed
• [Journal Article] Negative Human Papillomavirus Status and Excessive Alcohol Consumption are Significant Risk Factors for Second Primary Malignancies in Japanese Patients with Oropharyngeal Carcinoma (2014)
  • Author(s): Yuki Saito, Yasuhiro Ebihara, Tetsuo Ushiku, Go Omura, Kenya Kobayashi, Mizuo Ando, Takashi Sakamoto, Masashi Fukayama, Tatsuya Yamasoba, Takahiro Asakage
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 44 Issue: 6 Pages: 564-569
  • DOI: 10.1093/jjco/hyu042
  • Peer Reviewed
• [Journal Article] Salvage surgery for local residual or recurrent pharyngeal cancer after radiotherapy or chemoradiotherapy (2014)
  • Author(s): Go Omura MD, Yuki Saito MD, Mizuo Ando MD, Kenya Kobayashi MD, Yasuhiro Ebihara MD, Tatsuya Yamasoba MD, PhD andTakahiro Asakage MD, PhD
  • Journal Title: Laryngscope Volume: 未定 Issue: 9 Pages: 2075-2080
  • DOI: 10.1002/lary.24695
  • Peer Reviewed
• [Journal Article] Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma (2013)
  • Author(s): Yuki Saito MD1,*, Masafumi Yoshida MD1, Tetsuo Ushiku MD, PhD2, Go Omura MD1, Yasuhiro Ebihara MD1, Toshiyuki Shimono PhD3, Masashi Fukayama MD, PhD2, Tatsuya Yamasoba MD, PhD1 andTakahiro Asakage MD, PhD1
  • Journal Title: Cancer Volume: 119 Issue: 11 Pages: 2005-2011
  • DOI: 10.1002/cncr.28015
  • Peer Reviewed
• [Presentation] p16 expression in oropharyngeal and nasopharyngeal carcinoma. (2015)
  • Author(s): Yuki Saito,Tetsuo Ushiku,Go Omura, Masafumi Yoshida, Mizuo Ando,and Tatsuya Yamasoba.
  • Organizer: 13th Japan-Taiwan Conference n Otolaryngology-Head and Neck Surgery.
  • Place of Presentation: 学士会館（東京都・千代田区）
  • Year and Date: 2015-12-05
  • Int'l Joint Research / Invited
• [Presentation] A retrospective analysis of prognostic factors of maxillary squamous cell carcinoma. (2015)
  • Author(s): Yuki Saito, Go Omura, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, and Tatsuya Yamasoba.
  • Organizer: 4th Congress of Asia Society of Head and Neck Oncology. U40-027
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2015-06-03
  • Int'l Joint Research / Invited
• [Presentation] Analysis of the physical status of HPV-16 and TP53 codon 72 polymorphisms in Japanese patients with oropharyngeal squamous cell carcinoma (2014)
  • Author(s): Yuki Saito
  • Organizer: 5th World Congress of International Federation of Head and Neck Oncologic Societies (IFHNOS)
  • Place of Presentation: ニューヨーク、アメリカ
  • Year and Date: 2014-07-27 – 2014-07-30
• [Presentation] 当科における喉頭癌の治療成績の検討 (2014)
  • Author(s): 齊藤 祐毅
  • Organizer: 頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] Analysis of physical status of HPV-16 and TP53 codon 72 polymorphism in Japanese patients with oropharyngeal squamous cell carcinoma (2014)
  • Author(s): Yuki Saito, Mizuo Ando, Chisato Fujimoto, Kenya Kobayashi, Go Omura, Tatsuya Yamasoba, Takahiro Asakage
  • Organizer: IFHNOS 2014
  • Place of Presentation: アメリカ、ニューヨーク
• [Presentation] 当科における喉頭癌の治療成績の検討 (2014)
  • Author(s): 齊藤祐毅、小林謙也、小村豪、安藤瑞生、朝蔭孝宏、山岨達也
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Negative HPV status and alcohol consumption are significant risk factors for second primary malignancies in Japanese patients with oropharyngeal carcinoma (2013)
  • Author(s): Yuki Saito, Go Omura, Kenya Kobayashi, Mizuo Ando, Takashi Sakamoto, Tatsuya Yamasoba, Takahiro Asakage
  • Organizer: 12th Taiwan-Japan Conference on Otolaryngology Head and Neck Surgery
  • Place of Presentation: 台湾、台北
• [Presentation] 中咽頭扁平上皮癌におけるp16発現とISH-HPV発現の比較 (2013)
  • Author(s): 齊藤祐毅、小林謙也、小村豪、安藤瑞生、蝦原康宏、山岨達也、朝蔭孝宏
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 当科における頭頸部粘膜原発悪性黒色腫40例の臨床的検討 (2013)
  • Author(s): 齊藤祐毅、三谷浩樹、米川博之、福島啓文、佐々木徹、 新橋渉、瀬戸陽、北野睦三、小泉雄1、植木雄志、 神山亮介、川畑隆之、蛯名彩、足立充隆、小倉真理子、 川端一嘉
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
  • Invited