Detection of novel growth factors that regulate mucosal growth in acute otitis media

Research Project

Project/Area Number	25861534
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	The University of Tokyo
Principal Investigator	Suzukawa Keigo 東京大学, 医学部附属病院, 登録研究員 (50447398)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	急性中耳炎 / 増殖因子 / 粘膜過形成 / シグナル伝達
Outline of Final Research Achievements	Several basic experiments are performed in order to explore histopathologic and molecular mechanism of acute otitis media. We focused on HB-EGF, a growth factor that showed strong effect on middle ear mucosal growth. In this experiments we showed dominant downstream signaling pathways on HB-EGF action. Also we showed that HB-EGF played a role on mucosal growth induced by bacterial infection.