Detection of novel growth factors that regulate mucosal growth in acute otitis media
| Project/Area Number |
25861534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Suzukawa Keigo 東京大学, 医学部附属病院, 登録研究員 (50447398)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 急性中耳炎 / 増殖因子 / 粘膜過形成 / シグナル伝達 |
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| Outline of Final Research Achievements |
Several basic experiments are performed in order to explore histopathologic and molecular mechanism of acute otitis media. We focused on HB-EGF, a growth factor that showed strong effect on middle ear mucosal growth. In this experiments we showed dominant downstream signaling pathways on HB-EGF action. Also we showed that HB-EGF played a role on mucosal growth induced by bacterial infection.
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Report
(4 results)
Research Products
(2 results)
