Semaphorins control allergic rhinitis through neurological and immunological functions

• Project/Area Number: 25861558
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: Maeda Yohei 大阪大学, 医学部附属病院, 医員 (00636483)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アレルギー / アレルギー学

Outline of Final Research Achievements

In the allergic rhinitis mice model, a previous report showed that SEMA3A alleviates nasal symptoms through neural functions. We administrate SEMA3A receptor agonist and antagonist, but no remarkable change in phenotypes.
On the other hand, SEMA4A plays great roles in allergic inflammation. Thus, we generate SEMA4A-deficient allergic rhinitis model mice, but phenotypes of this mice model vary widely. Furthermore, we continue to do experiment in this mice model or other allergic rhinitis model.