| Project/Area Number |
25861573
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ヒト鼻粘膜上皮 / 呼吸器ウイルス / RSウイルス / 上皮バリア機能 / 抗NF-ｋB作用 / elF2α / ヒト鼻粘膜 / 上皮 / 自然免疫 / NF-kB |
|---|
| Outline of Final Research Achievements |
Respiratory syncytial virus (RSV) is one of the most important pathogens for bronchitis, pneumoniae and asthma in infants and young childrens. However, an effective vaccine and anti-viral therapy for RSV infection have not yet been developed. RSV replicats in the airway mucosa, where it may produce umcomplicated upper respiratory infection or spread distally to lower airways, producing more sever lower respiratory tract infection. In this study, we showed that curcumin which has multipharmacological effects including inhibition of NF-kB activation, proteasome activation and elF2 alpha dephosphorylation prevented the replication of RSV in human nasal epithelial cells. Inhibition of RSV in HNECs by curcumin may be effective treatment and prevention for severe lower respiratory disease.
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