Establishment of the method to presume binocular visual field considering dominance of eyes

• Project/Area Number: 25861619
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: The University of Tokyo
• Principal Investigator: MAYAMA Chihiro 東京大学, 医学部附属病院, 講師 (50570701)
• Research Collaborator: ASAOKA Ryo 東京大学, 眼科視覚矯正科, 病院講師
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 緑内障 / 視野 / 眼優位性 / QOL / QoVL / 両眼視

Outline of Final Research Achievements

The method to evaluate dominance of eyes had been established but it had not a large impact on speculating binocular visual field. It was important to apply the item response theory (Rasch analysis) when investigating the patient’s quality of life. It was also advantageous to apply machine learning methods, such as the random Forests method, when predicting patients’ quality of life form the results of visual field. When interpreting the results of visual field measurement, it is useful to evaluate the reliability of visual field using the Gazetracking results (eye movements). Also, when analyzing the progression rate of visual field, it is useful to apply the least absolute shrinkage and selection operator (Lasso) regression and also cluster-wise regression method.

Research Products

• [Journal Article] Applying 'Lasso' regression to predict future visual field progression in glaucoma patients. (2015)
  • Author(s): Y. Fujino, H. Murata, C. Mayama and R. Asaoka
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Pages: 2334-9
  • DOI: 10.1167/iovs.15-16445
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Validating the Sumi Quality of Life Questionnaire with Rasch Analysis. (2014)
  • Author(s): Hirasawa H, Murata H, Mayama C, Asaoka R.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55(9) Pages: 5776-82
  • DOI: 10.1167/iovs.14-14390
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of various machine learning methods to predict vision related quality of life from visual field data and visual acuity in patients with glaucoma (2014)
  • Author(s): Hirasawa H, Murata H, Mayama C, Araie M, Asaoka R.
  • Journal Title: Br J Ophthalmol Volume: 98(9) Pages: 1230-1235
  • DOI: 10.1136/bjophthalmol-2013-304319
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An Objective Evaluation of Gaze Tracking in Humphrey Perimetry and the Relation With the Reproducibility of Visual Fields: A Pilot Study in Glaucoma. (2014)
  • Author(s): Y. Ishiyama, H. Murata, C. Mayama and R. Asaoka
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Pages: 8149-52
  • DOI: 10.1167/iovs.14-15541
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clustering visual field test points based on rates of progression to improve the prediction of future damage. (2014)
  • Author(s): Hirasawa K, Murata H, Hirasawa H, Mayama C, Asaoka R.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Pages: 7681-5
  • DOI: 10.1167/iovs.14-15040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A method to measure visual field sensitivity at the edges of glaucomatous scotomata. (2014)
  • Author(s): Aoyama Y, Murata H, Tahara M, Yanagisawa M, Hirasawa K, Mayama C, Asaoka R.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: in press Pages: 2584-91
  • DOI: 10.1167/iovs.13-13616
  • Peer Reviewed
• [Journal Article] Impact of better and worse eye damage on quality of life in advanced glaucoma. (2014)
  • Author(s): Okamoto M, Sugisaki K, Murata H, Hirasawa H, Mayama C, Asaoka R.
  • Journal Title: Sci Rep. Volume: 4 Pages: 4144-4144
  • DOI: 10.1038/srep04144
  • Peer Reviewed
• [Journal Article] Glaucoma-induced optic disc morphometric changes and glaucoma diagnostic ability of Heidelberg Retina Tomograph II in highly myopic eyes (2014)
  • Author(s): Mayama C, Tsutsumi T, Saito H, Asaoka R, Tomidokoro A, Iwase A, Otani S, Miyata K, Araie M.
  • Journal Title: PLoS One. Volume: 9
  • DOI: 10.1371/journal.pone.0086417
  • Peer Reviewed
• [Journal Article] Circle- and grid-wise analyses of peripapillary nerve fiber layers by spectral domain optical coherence tomography in early-stage glaucoma. (2013)
  • Author(s): Mayama C, Saito H, Hirasawa H, Konno S, Tomidokoro A, Araie M, Iwase A, Ohkubo S, Sugiyama K, Otani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 54 Pages: 4519-26
  • DOI: 10.1167/iovs.13-11603
  • Peer Reviewed
• [Journal Article] Identifying areas of the visual field important for quality of life in patients with glaucoma (2013)
  • Author(s): Murata H, Hirasawa H, Aoyama Y, Sugisaki K, Araie M, Mayama C, Aihara M, Asaoka R.
  • Journal Title: PLoS One. Volume: 8
  • DOI: 10.1371/journal.pone.0058695
  • Peer Reviewed
• [Presentation] MDとゲイズトラッキング、視野信頼性指標の関連に関する検討 (2015)
  • Author(s): 石山 由佳子、村田博史、間山千尋、朝岡亮
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16 – 2015-04-19
• [Presentation] ゲイズトラッキングと視野検査の再現性の関連についての検討 (2014)
  • Author(s): 石山 由佳子、村田博史、間山千尋、朝岡亮
  • Organizer: 第68回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] Dividing visual field into clusters according to the progression speed and investigating the usefulness of the clusters to predict the progression. (2014)
  • Author(s): Hirasawa K, Murata H, Mayama C, Asaoka R.
  • Organizer: World Ophthalmology Conference
  • Place of Presentation: Tokyo
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] Reassessing the quality of life questionnaire, ‘Sumi Questionnaire’ developed in Japan with Rasch model analysis. (2014)
  • Author(s): Hirasawa H, Murata H, Mayama C, Araie M, Asaoka R.
  • Organizer: World Ophthalmology Conference
  • Place of Presentation: Tokyo
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] A novel method to predicting quality of visual life and identifying essential visual field locations (2013)
  • Author(s): Hirasawa H, Murata H, Aoyama Y, Araie M, Mayama C, Aihara M, Asaoka R
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: シアトル、米国
• [Presentation] The relationship between visual acuity and central visual field on vision related quality of life in advanced glaucomatous patients (2013)
  • Author(s): Okamoto M, Murata H, Araie M, Hirasawa H, Mayama C, Asaoka R
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: シアトル、米国