| Project/Area Number |
25861628
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
UJI Akihito 京都大学, 医学(系)研究科(研究院), 助教 (60534302)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 補償光学 / 糖尿病網膜症 / 網膜循環 / 眼光学 / 糖尿病 |
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| Outline of Final Research Achievements |
Diabetic retinopathy is one of the leading causes of visual impairment in japan. Adaptive Optics Scanning Laser Ophthalmoscopy (AO-SLO) has enabled noninvasive and direct monitoring of blood flow. We analyzed the retinal hemorheologic characteristics using AO-SLO in normal subjects, diabetic patients without diabetic retinopathy (NDR), and diabetic patients with nonproliferative diabetic retinopathy (NPDR). Although differences in erythrocyte aggregate velocity in the parafoveal network were found between normal subjects and NPDR patients, but not between normal subjects and NDR patients, erythrocyte aggregates in NDR patients and NPDR patients showed lower elongation rates than those observed in normal subjects. Differences in the proportion of each type of ST image were found between normal subjects and diabetic patients, suggesting that ST images can be used to visualize subclinical rheologic changes related to retinopathy in diabetic patients.
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