| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Neural crest cells (NCCs) have the ability to differentiate into various types of cells and contribute various tissues. We took notice of the multipotency of NCCs and considered the possibility that NCCs are involved in scarless fetal wound healing. To address the role of NCCs in scarless wound healing, we employed iPSC-derived NCCs and a mouse corneal scarring model. We found that iPSC-derived NCCs injection into injured mouse cornea significantly reduced the scar formation due to injury compared with fibroblast injection. Cytokine array analysis revealed that the expression patterns of cytokines in iPSC-derived NCCs correspond to that in fetal wound healing. In particular, low expression levels of inflammatory cytokines IL-6 and IL-8 were found. These results suggest that scarless wound healing by iPSC-derived NCCs was caused by anti-inflammatory cytokines.
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