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Mechanism of inhibition of Muller cell dedifferentiation and proliferation

Research Project

Project/Area Number 25861656
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionTokyo Women's Medical University

Principal Investigator

SAITOH FUMINORI  東京女子医科大学, 医学部, 助教 (50435723)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsミュラー細胞 / 網膜
Outline of Final Research Achievements

We analyzed the mechanism of Muller cell dedifferentiation and proliferation in rodent models of photoreceptor damage. We examined expression Notch1 and Notch2 at mRNA and protein levels after photoreceptor damage. We found that expression of Notch1 and Notch2 mRNA are highly induced. Notch2 protein expression is also changes, accordingly. In contrast, we didn't detect Notch1 protein. We found that expression of Notch1 protein leveles increse with proteasome inhibitor. Our findings reveal that the degradation of Notch protein by ubiquitin-proteasome system may be one of the mechanisms that limit retinal regeneration in mammals.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 Other

All Presentation (5 results)

  • [Presentation] 発生期マウス網膜におけるエピジェネティク因子群の発現解析2015

    • Author(s)
      須藤則広、齋藤文典、藤枝弘樹
    • Organizer
      第120回 日本解剖学会 総会・全国学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 網膜傷害時におけるミュラーグリアの貪食能獲得2015

    • Author(s)
      蒋池かおり、齋藤文典、藤枝弘樹
    • Organizer
      第120回 日本解剖学会 総会・全国学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 網膜変性後Müllerグリアに起こるDNA損傷と細胞死について

    • Author(s)
      野村かおり、齋藤文典、早川享、根岸春樹、藤枝弘樹
    • Organizer
      第36回 日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス網膜発生期におけるエピジェネティク因子群の発現解析

    • Author(s)
      須藤則広、齋藤文典、藤枝弘樹
    • Organizer
      第119 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report
  • [Presentation] 網膜の変性によるMüllerグリアの細胞周期進入とDNA損傷応答

    • Author(s)
      野村かおり、齋藤文典、蒋池勇太、藤枝弘樹
    • Organizer
      第119 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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