| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Total porphyrin production was increased when P. aeruginosa was treated with ALA, while PpIX was also increased markedly when ALA and EDTA were added simultaneously. A bactericidal effect on P. aeruginosa was not observed when PDT was conducted using ALA alone, although a bacteriostatic effect was observed after treatment with both ALA and EDTA.The optimal LED wavelength for PDT was 410 nm. Further investigations are needed to determine whether PDT combined with ALA and EDTA treatment has a bacteriostatic effect in vivo.
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