Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study
Project/Area Number |
25861717
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Emergency medicine
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
MAKINO HIROSHI 浜松医科大学, 医学部附属病院, 講師 (10397408)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 脳動脈瘤 / 肥満細胞 / マウス / くも膜下出血 / 画像診断 / MRI / マウスモデル / 脳動脈瘤破裂 / 国際情報交換 / 米国 |
Outline of Final Research Achievements |
In the animal model of abdominal aneurysm, inhibitor of releasing chemical mediator from the Mast cell prevented growth of abdominal aortic diameter. This feasibility study aimed to prevent intracranial aneurysm (IA) rupture using the inhibitor of releasing chemical mediator from the Mast cell. Our experiment revealed that inhibitor of releasing chemical mediator from the Mast cell prevented aneurysm rupture in our mouse model of IA. This result may implicate human IA treatment in future.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Estrogen protects against intracranial aneurysm rupture in ovariectomized mice2014
Author(s)
Tada Y, Wada K, Shimada K, Makino H, Liang EI, Murakami S, Kudo M, Shikata F, Silva RAP, Kitazato KT, Hasan DM, Kanematsu Y, Nagahiro S, Hashimoto T
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Journal Title
Hypertension
Volume: 63
Issue: 6
Pages: 1339-1344
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Roles of estrogen in the formation of inctracranial aneurysms in ovariectomized female mice2014
Author(s)
Tada Y, Makino H, Furukawa H, Shimada K, Wada K, Liang EI, Murakami S, Kudo M, Kung DK, Hasan DM, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T
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Journal Title
Neurosurgery
Volume: 75
Issue: 6
Pages: 690-695
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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