Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study

• Project/Area Number: 25861717
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MAKINO HIROSHI 浜松医科大学, 医学部附属病院, 講師 (10397408)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 脳動脈瘤 / 肥満細胞 / マウス / くも膜下出血 / 画像診断 / ＭＲＩ / マウスモデル / 脳動脈瘤破裂 / 国際情報交換 / 米国

Outline of Final Research Achievements

In the animal model of abdominal aneurysm, inhibitor of releasing chemical mediator from the Mast cell prevented growth of abdominal aortic diameter. This feasibility study aimed to prevent intracranial aneurysm (IA) rupture using the inhibitor of releasing chemical mediator from the Mast cell. Our experiment revealed that inhibitor of releasing chemical mediator from the Mast cell prevented aneurysm rupture in our mouse model of IA. This result may implicate human IA treatment in future.

Research Products

• [Journal Article] Translational research using a mouse model of intracranial aneurysm. (2014)
  • Author(s): Wada K, Makino H, Shimada K, Shikata F, Kuwabara A, Hashimoto T
  • Journal Title: Transl Stroke Res. Volume: 5 Issue: 2 Pages: 248-251
  • DOI: 10.1007/s12975-013-0296-8
  • Peer Reviewed / Open Access
• [Journal Article] Roles of hypertension in the rupture of intracranial aneurysms (2014)
  • Author(s): Tada Y, Wada K, Shimada K, Makino H, Liang EI, Murakami S, Kudo M, Kitazato KT, Nagahiro S, Hashimoto T
  • Journal Title: Stroke Volume: 45 Issue: 2 Pages: 579-586
  • DOI: 10.1161/strokeaha.113.003072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Estrogen protects against intracranial aneurysm rupture in ovariectomized mice (2014)
  • Author(s): Tada Y, Wada K, Shimada K, Makino H, Liang EI, Murakami S, Kudo M, Shikata F, Silva RAP, Kitazato KT, Hasan DM, Kanematsu Y, Nagahiro S, Hashimoto T
  • Journal Title: Hypertension Volume: 63 Issue: 6 Pages: 1339-1344
  • DOI: 10.1161/hypertensionaha.114.03300
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Roles of estrogen in the formation of inctracranial aneurysms in ovariectomized female mice (2014)
  • Author(s): Tada Y, Makino H, Furukawa H, Shimada K, Wada K, Liang EI, Murakami S, Kudo M, Kung DK, Hasan DM, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T
  • Journal Title: Neurosurgery Volume: 75 Issue: 6 Pages: 690-695
  • DOI: 10.1227/neu.0000000000000528
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Serial imaging of mouse cerebral arteries using a conventional 3T MR — a feasibility study using a mouse model of intracranial aneurysm (2014)
  • Author(s): Makino H, Hokamura K, Natsume T, Kimura T, Kamio Y, Katoh T, Sato S, Hashimoto T, Umemura K
  • Organizer: World congress of Stroke 2014
  • Place of Presentation: Istanbul
  • Year and Date: 2014-10-23
• [Presentation] Subarachnoid Hemorrhage Decreases Isoflurane Requirement in Mouse Model of Intracranial Aneurysm (2014)
  • Author(s): Kimura T, Makino H, Katoh T, Sato S
  • Organizer: American Society of Anesthesiologists 2014 annual meeting
  • Place of Presentation: New Orleans
  • Year and Date: 2014-10-13
• [Presentation] Roles of Mast Cells in the Rupture of Intracranial Aneurysms (2013)
  • Author(s): Kosuke Wada, Yoshiteru Tada, Hiroshi Makino, Mari Kudo, Shoko Murakami, Kenji Shimada, Atsushi Kuwabara, Makoto Ozaki, Tomoki Hashimoto,
  • Organizer: 米国麻酔科学会2013年年次集会
  • Place of Presentation: サンフランシスコ市