Pilot studies for the anti-inflammatory therapy targeting newly discovered Damage-associated molecular pattern molecules (DAMPs) family, Heat Shock Protein 27(HSPB8).

• Project/Area Number: 25861722
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Oita University
• Principal Investigator: aso yuiko 大分大学, 医学部, 研究支援者 (60635358)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: DAMPs / Heart Shock Protein 27 / 急性炎症性反応 / LPS / 急性肺障害 / HeatShockProtein27 / 急性炎症反応 / Heat Shock Protein27 / Heat Shock Protein 27 / 急性肺傷害

Outline of Final Research Achievements

Severe organ failure is caused by many inflammatory responses, one of which is mediated by host molecules known as Damage-associated molecular pattern molecules (DAMPs). DAMPs are released from cell inside and are mainly cytosolic or nuclear proteins, which initiate and exaggerate the tissue inflammations and damages. In this study, we investigated the new mediators acting as DAMPs, it is showed that Heat Shock Protein 27(HSPB8) is increased in lipopolysuccaride (LPS) treated rats. Recombinant HSPB8 induced acute lung injury. It is considered that HSPB8 is acting as DAMPs and that new anti-inflammatory therapy targeting HSPB8 may be effective for protecting severe organ failure.