The study of blood clotting and venous repair regulated by a novel protein
Project/Area Number |
25861756
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
ASANO Satoshi 広島大学, 医歯薬保健学研究院(歯), 助教 (30570535)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 細胞移動 / PI3-kinase / 細胞骨格 / 創傷治癒 / イノシトールリン脂質 / シグナル伝達 / 血小板増殖因子 |
Outline of Final Research Achievements |
To repair damaged tissues, fibroblasts form lamellipodia at its leading edge and migrate to the damaged tissues, resulting in contribution of wound healing. The lamellipodia formation is regulated by the metabolism of PI(4,5)P2, an inositol phospholipid, into PI(3,4,5)P3. In this study, we revealed a possible regulatory mechanism by phospholipase C-related catalytically inactive protein (PRIP), an inositol phospholipid-binding partner, in PDGF-induced cell migration.
|
Report
(3 results)
Research Products
(8 results)
-
-
[Journal Article] Phospholipase C-Related Catalytically Inactive Protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase2014
Author(s)
T. Okumura, K. Harada, K. Oue, J. Zhang, S. Asano, M. Hayashiuchi, A. Mizokami, H. Tanaka, M. Irifune, N. Kamata, M. Hirata, and T. Kanematsu.
-
Journal Title
PLoS One
Volume: 9
Issue: 6
Pages: e100559-e100559
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-