Reactionary dentin formation by alkali-sensing TRP channels
Project/Area Number |
25861762
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Tokyo Dental College |
Principal Investigator |
KIMURA Maki 東京歯科大学, 歯学部, その他 (90582346)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 象牙芽細胞 / アルカリ刺激 |
Outline of Final Research Achievements |
In odontoblasts, alkaline stimuli activate the intracellular Ca2+ signaling pathway via Ca2+ influx from the extracellular space and intracellular Ca2+ release. These high-pH induced Ca2+ mobilizations showed dependence on extracellular Ca2+; TRPA1 channels mediated the Ca2+ influx. The plasma membrane and intracellular high-pH-sensing mechanisms in odontoblasts may play an important role in cellular functions during dentinogenesis induced by calcium hydroxide.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Odontoblasts as sensory receptors: transient receptor potential channels, pannexin-1, and ionotropic ATP receptors mediate intercellular odontoblast-neuron signal transduction2015
Author(s)
Shibukawa, Y., Sato, M., Kimura, M., Sobhan, U., Shimada, M., Nishiyama, A., Kawaguchi, A., Soya, M., Kuroda, H., Katakura, A., Ichinohe, T., and Tazaki, M.
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Journal Title
Pflügers Archiv European Journal of Physiology
Volume: 467
Issue: 4
Pages: 843-863
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Ca2+ signaling activated by alkaline environment in rat odontoblasts2015
Author(s)
Kimura Maki, Sato Masaki, Kojima Yuki, Higashikawa Asuka, Nishiyama Akihiro, Satou Ryoichi, Shiozaki Yuuta, Shimada Miyuki, Ogura Kazuhiro, Mochizuki Hiroyuki, Shibukawa Yoshiyuki, Tazaki Masakazu
Organizer
第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
Place of Presentation
神戸
Year and Date
2015-03-21 – 2015-03-23
Related Report
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[Presentation] Ca2+ signaling activated by alkali-sensing mechanisms in rat odontoblasts2015
Author(s)
M. Kimura, M. Sato, A. Nishiyama, Y. Kojima, A. Higashikawa, M. Shimada, K. Ogura, H. Mochizuki, Y. Shibukawa, M. Tazaki
Organizer
93rd General Session & Exhibition of the International Association for Dental Research
Place of Presentation
Boston, USA
Year and Date
2015-03-11 – 2015-03-14
Related Report
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[Presentation] Extracellular H+ activates intra- and trans-cellular calcium signaling in odontoblasts2015
Author(s)
M. Sato, K. Kurasawa, M. Kimura, Y. Kojima, A. Higashikawa, A. Nishiyama, Y. Shiozaki, R. Sato, M. Shimada, K. Ogura, H. Mochizuki, Y. Shibukawa, M. Tazaki
Organizer
93rd General Session & Exhibition of the International Association for Dental Research
Place of Presentation
Boston, USA
Year and Date
2015-03-11 – 2015-03-14
Related Report
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