• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Reactionary dentin formation by alkali-sensing TRP channels

Research Project

Project/Area Number 25861762
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionTokyo Dental College

Principal Investigator

KIMURA Maki  東京歯科大学, 歯学部, その他 (90582346)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords象牙芽細胞 / アルカリ刺激
Outline of Final Research Achievements

In odontoblasts, alkaline stimuli activate the intracellular Ca2+ signaling pathway via Ca2+ influx from the extracellular space and intracellular Ca2+ release. These high-pH induced Ca2+ mobilizations showed dependence on extracellular Ca2+; TRPA1 channels mediated the Ca2+ influx. The plasma membrane and intracellular high-pH-sensing mechanisms in odontoblasts may play an important role in cellular functions during dentinogenesis induced by calcium hydroxide.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (30 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (24 results)

  • [Journal Article] Odontoblasts as sensory receptors: transient receptor potential channels, pannexin-1, and ionotropic ATP receptors mediate intercellular odontoblast-neuron signal transduction2015

    • Author(s)
      Shibukawa, Y., Sato, M., Kimura, M., Sobhan, U., Shimada, M., Nishiyama, A., Kawaguchi, A., Soya, M., Kuroda, H., Katakura, A., Ichinohe, T., and Tazaki, M.
    • Journal Title

      Pflügers Archiv European Journal of Physiology

      Volume: 467 Issue: 4 Pages: 843-863

    • DOI

      10.1007/s00424-014-1551-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] グアヤコールは象牙芽細胞の細胞内Ca2+流入を活性化する2013

    • Author(s)
      隝田みゆき,津村麻記,佐藤正樹,Sobhan Ubaidus,大多和由美,山下秀一郎,田﨑雅和, 澁川義幸
    • Journal Title

      歯科学報

      Volume: 116(6) Pages: 593-598

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts.2013

    • Author(s)
      Maki Tsumura, Ubaidus Sobhan, Masaki Sato, Miyuki Shimada, Akihiro Nishiyama, Aya Kawaguchi, Manabu Soya, Hidetaka Kuroda, Masakazu Tazaki, Yoshiyuki Shibukawa
    • Journal Title

      PLoS One

      Volume: 8 Issue: 12 Pages: e82233-e82233

    • DOI

      10.1371/journal.pone.0082233

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization and distribution of functional temperature-sensitive TRP channels in the salivary glands2013

    • Author(s)
      U Sobhan, M Sato, T Shinomiya, M Okubo, M Tsumura, T Muramatsu, M Kawaguchi, M Tazaki, Y Shibukawa
    • Journal Title

      Cell and Tissue Research

      Volume: 354 Issue: 2 Pages: 507-519

    • DOI

      10.1007/s00441-013-1691-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 象牙芽細胞におけるtransient receptor potential melastatin subfamily member 8チャネルの発現の検索2013

    • Author(s)
      高橋史子,津村麻記,Sobhan Ubaidus, 佐藤正樹,田﨑雅和, 澁川義幸
    • Journal Title

      医学と生物学

      Volume: 157(6-2) Pages: 985-990

    • NAID

      40019705529

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sodium-calcium exchangers in rat trigeminal ganglion neurons.2013

    • Author(s)
      Hidetaka Kuroda, Ubaidus Sobhan, Masaki Sato, Maki Tsumura, Tatsuya Ichinohe, Masakazu Tazaki, Yoshiyuki Shibukawa
    • Journal Title

      Molecular Pain

      Volume: 9 Pages: 22-22

    • DOI

      10.1186/1744-8069-9-22

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Ca2+ signaling activated by alkaline environment in rat odontoblasts2015

    • Author(s)
      Kimura Maki, Sato Masaki, Kojima Yuki, Higashikawa Asuka, Nishiyama Akihiro, Satou Ryoichi, Shiozaki Yuuta, Shimada Miyuki, Ogura Kazuhiro, Mochizuki Hiroyuki, Shibukawa Yoshiyuki, Tazaki Masakazu
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Guaiacol activates TRPV3 channels in mouse odontoblast-lineage cells2015

    • Author(s)
      Miyuki Shimada, Maki Kimura, Masaki Sato, Ubaidus Sobhan, Masakazu Tazaki, Yoshiyuki Shibukawa
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intercellular odontoblast networks via extracellular glutamate2015

    • Author(s)
      Nishiyama Akihiro, Sato Masaki, Kimura Maki, Katakura Akira, Tazaki Masakazu, Shibukawa Yoshiyuki
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional expression of P2X7 receptors in odontoblasts2015

    • Author(s)
      Shiozaki Yuuta, Sato Masaki, Kimura Maki, Shibukawa Yoshiyuki, Tazaki Masakazu
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Voltage-dependent calcium influx pathway in rat odontoblasts2015

    • Author(s)
      Kojima Yuki, Higashikawa Asuka, Kimura Maki, Sato Masaki, Ogura Kazuhiro, Mochizuki Hiroyuki, Shibukawa Yoshiyuki, Tazaki Masakazu
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Merkel cells transduce mechanical stimuli and release neurotransmitters2015

    • Author(s)
      Higashikawa Asuka, Kojima Yuki, Kimura Maki, Sato Masaki, Ogura Kazuhiro, Mochizuki Hiroyuki, Shibukawa Yoshiyuki, Tazaki Masakazu
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ca2+ signaling activated by alkali-sensing mechanisms in rat odontoblasts2015

    • Author(s)
      M. Kimura, M. Sato, A. Nishiyama, Y. Kojima, A. Higashikawa, M. Shimada, K. Ogura, H. Mochizuki, Y. Shibukawa, M. Tazaki
    • Organizer
      93rd General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Intercellular odontoblast-odontoblast Ca2+ signaling via extracellular glutamate2015

    • Author(s)
      A. Nishiyama, M. Sato, M. Kimura, A. Katakura, Y. Shibukawa, M. Tazaki
    • Organizer
      93rd General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Extracellular H+ activates intra- and trans-cellular calcium signaling in odontoblasts2015

    • Author(s)
      M. Sato, K. Kurasawa, M. Kimura, Y. Kojima, A. Higashikawa, A. Nishiyama, Y. Shiozaki, R. Sato, M. Shimada, K. Ogura, H. Mochizuki, Y. Shibukawa, M. Tazaki
    • Organizer
      93rd General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット象牙芽細胞における電位依存性Ca2+透過性チャネル発現の検討2014

    • Author(s)
      小島佑貴,東川明日香,木村麻記,佐藤正樹,澁川義幸,田崎雅和
    • Organizer
      第298回東京歯科大学学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] メルケル細胞は機械刺激を受容し神経伝達をする2014

    • Author(s)
      東川明日香,小島佑貴,木村麻記,佐藤正樹,小倉一宏,望月浩幸,澁川義幸,田崎雅和
    • Organizer
      第298回東京歯科大学学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 象牙芽細胞におけるイオンチャネル型ATP受容体サブタイプ(P2X7)の機能発現2014

    • Author(s)
      塩崎雄大,佐藤正樹,木村麻記,澁川義幸,佐藤亨,田崎雅和
    • Organizer
      第298回東京歯科大学学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 象牙芽細胞における酸感受性タンパク質の機能検索2014

    • Author(s)
      倉澤馨,佐藤正樹,木村麻記,小島佑貴,東川明日香,小倉一宏,望月浩幸,川口綾,西山明宏,塩崎雄大,佐藤涼一,澁川義幸,田崎雅和
    • Organizer
      第298回東京歯科大学学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Odontoblast hydrodynamic receptor theory:TRP チャネルによって仲介される象牙質痛覚発現機構2014

    • Author(s)
      澁川義幸,佐藤正樹,木村麻記,小島佑貴,東川明日香,小倉一宏,望月浩幸,田崎雅和
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 象牙芽細胞のアルカリ感受性象牙質形成機構の解明2014

    • Author(s)
      木村麻記,佐藤正樹,小島佑貴,東川明日香,隝田みゆき,小倉一宏,望月浩幸,田崎雅和,澁川義幸
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 象牙芽細胞における酸・機械刺激誘発性Ca2+流入はamilorideで抑制される2014

    • Author(s)
      倉澤馨,佐藤正樹,木村麻記,小島佑貴,東川明日香,小倉一宏,望月浩幸,隝田みゆき,澁川義幸,田崎雅和
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] グアヤコールの前投与は象牙芽細胞における低浸透圧刺激誘発性Ca2+流入を抑制する2014

    • Author(s)
      隝田みゆき,木村麻記,佐藤正樹,田崎雅和,澁川義幸
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] グルタミン酸による象牙芽細胞-象牙芽細胞間シグナル伝達2014

    • Author(s)
      西山明宏,佐藤正樹,木村麻記,田崎雅和,片倉朗,澁川義幸
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Merkel細胞は機械刺激を受容し神経伝達を行う2014

    • Author(s)
      東川明日香,小島佑貴,木村麻記,佐藤正樹,小倉一宏,望月浩幸,澁川義幸,田崎雅和
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 象牙芽細胞におけるアルカリ感受性の検討2013

    • Author(s)
      津村麻記,佐藤正樹,Sobhan Ubaidus,児玉紗耶香,隝田みゆき,西山明宏,田﨑雅和, 澁川義幸
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス由来象牙芽細胞における細胞膜伸展受容TRPチャネルとNa+-Ca2+ exchangerの機能連関2013

    • Author(s)
      佐藤正樹,津村麻記,Sobhan Ubaidus,児玉紗耶香,隝田みゆき,西山明宏,望月浩幸,小倉一宏,田﨑雅和, 澁川義幸
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Research-status Report
  • [Presentation] グアヤコールは象牙芽細胞のTRPV3チャネルに作用する2013

    • Author(s)
      隝田みゆき,津村麻記,佐藤正樹,Sobhan Ubaidus,山下秀一郎,田﨑雅和, 澁川義幸
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Research-status Report
  • [Presentation] Odontoblast as sensory receptor cell: TRP channels, pannexin 1 and P2X3 receptor coupling mediate sensory transduction in dentin2013

    • Author(s)
      Y Shibukawa, M Sato, M Tsumura, H Kuroda, U Sobhan, M Tazaki
    • Organizer
      11th International Conference on Tooth Morphorogenesis and Differentiation
    • Place of Presentation
      France, La Londe Les Maures
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of TRPM8 and TRPA1 channels in rat odontoblasts2013

    • Author(s)
      M Sato, M Tsumura, U Sobhan, M Tazaki, Y Shibukawa
    • Organizer
      11th International Conference on Tooth Morphorogenesis and Differentiation
    • Place of Presentation
      France, La Londe Les Maures
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi