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Cell competition in lateral invasion fronts of oral carcinoma in-situ

Research Project

Project/Area Number 25861768
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNiigata University

Principal Investigator

ABE Tatsuya  新潟大学, 医歯学総合病院, レジデント (70634856)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔上皮内癌 / 口腔扁平上皮癌 / 細胞競合 / 免疫組織化学 / 細胞死 / 口腔異型上皮
Outline of Final Research Achievements

Histopathologically, oral carcinoma in-situ (CIS) foci are frequently confronted with non/less malignant lesions including epithelial dysplasia when they invade laterally within the epithelial compartment. In those interfaces, cell competition-like phenomena must occur between CIS cells and less malignant cells. Thus, I have investigated such lateral invasion fronts of oral CIS against normal/dysplasitic epithelia in the tissue section level. There were apoptotic bodies (60%) and eosinophilic hyaline bodies (36%) in SCC/CIS sides of the interfaces. In addition, LC/MS/MS proteomics analysis detected interferon-induced proteins in those interface-adjacent carcinoma cells. These findings suggested carcinoma cells might be losers in cell competition with less malignance cells as winners, and that these cell competitive conditions are induced by cytokines shed from both side cells.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (40 results)

All 2014 2013

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (27 results)

  • [Journal Article] Simultaneous immunolocalization of desmoglein 3 and IgG4 in oral pemphigus vulgaris: IgG4 predominant autoantibodies in its pathogenesis.2014

    • Author(s)
      Abe T, Maruyama S, Babkair H, Yamazaki M, Cheng J, Saku T
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: 該当なし Issue: 10 Pages: 850-856

    • DOI

      10.1111/jop.12290

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Perlecan-enriched intercellular space of junctional epithelium provides primary infrastructure for leucocyte migration through squamous epithelial cells2014

    • Author(s)
      Maruyama S, Itagaki M, Ida-Yonemochi H, Kubota T, Yamazaki M, Abe T, Yoshie H, Cheng J, Saku T
    • Journal Title

      Histochemistry and Cell Biology

      Volume: online published Issue: 3 Pages: 297-305

    • DOI

      10.1007/s00418-014-1198-x

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional visualization of perlecan-rich neoplastic stroma induced concurrently with the invasion of oral squamous cell carcinoma2014

    • Author(s)
      Maruyama S, Shimazu Y, Kudo T, Sato K, Yamazaki M, Abe T, Babkair H, Cheng J, Aoba T, Saku T
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: online published Issue: 8 Pages: 627-36

    • DOI

      10.1111/jop.12184

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages2014

    • Author(s)
      Essa AAM, Yamazaki M, Maruyama S, Abe T, Babkair H, Cheng J, Saku T
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: in press Issue: 10 Pages: 778-84

    • DOI

      10.1111/jop.12197

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraoperative assessment of surgical margins of oral squamous cell carcinoma using frozen sections: a practical clinicopathological management for recurrences2014

    • Author(s)
      Miyota S, Kobayashi T, Abe T, Miyajima H, Nagata M, Hoshina H, Kobayashi T, Takagi R, Saku T
    • Journal Title

      Biomed Research International

      Volume: - Pages: 1-9

    • DOI

      10.1155/2014/823968

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells.2014

    • Author(s)
      Yamazaki M, Maruyama S, Abe T, Essa A, Babkair H, Cheng J, Saku T.
    • Journal Title

      Lab Invest.

      Volume: 94(11) Issue: 11 Pages: 1260-72

    • DOI

      10.1038/labinvest.2014.108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature.2014

    • Author(s)
      Yamazaki M, Maruyama S, Abe T, Babkair H, Fujita H, Takagi R, Koyama JI, Hayashi T, Cheng J, Saku T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol.

      Volume: 118(1) Issue: 1 Pages: e12-e18

    • DOI

      10.1016/j.oooo.2013.08.032

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.2013

    • Author(s)
      Abe T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, Shingaki S, Kobayashi T, Hayashi T, Cheng J, Saku T.
    • Journal Title

      Hum Pathol.

      Volume: 45(1) Issue: 1 Pages: 110-8

    • DOI

      10.1016/j.humpath.2013.08.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation2013

    • Author(s)
      Masayuki Tsuneki
    • Journal Title

      Virchows Archiv

      Volume: 462 Issue: 3 Pages: 297-305

    • DOI

      10.1007/s00428-012-1359-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemophagocytosis-mediated keratinization in oral carcinoma in-situ and squamous cell carcinoma: a possible histopathogenesis of keratin pearls2013

    • Author(s)
      Al-Eryani K, Cheng J, Abe T, Yamazaki M, Maruyama S, Tsuneki M, Essa A, Babkair H, Saku T
    • Journal Title

      Journal of Cellular Physiology

      Volume: 228 Issue: 10 Pages: 1977-1988

    • DOI

      10.1002/jcp.24364

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells2013

    • Author(s)
      Masayuki Tsuneki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 434 Issue: 1 Pages: 124-130

    • DOI

      10.1016/j.bbrc.2013.03.057

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inflammatory histopathogenesis of nasopalatine duct cyst : a clinicopathological study of 41 cases2013

    • Author(s)
      Masayuki Tsuneki
    • Journal Title

      Oral Diseases

      Volume: 19 Issue: 4 Pages: 415-424

    • DOI

      10.1111/odi.12022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Central neurofibroma of the mandible: Report of a case and review of the literature.2013

    • Author(s)
      Metwaly H, Cheng J, Maruyama S, Yamazaki M, Essa A, Abe T, Babkair H, Hoshina H, Takagi R, Hayashi T, Saku T
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 25 Issue: 3 Pages: 294-298

    • DOI

      10.1016/j.ajoms.2012.12.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔天疱瘡はデスモグレイン3とIgG4の点状共局在様式から病理組織 診断でも確定できる2014

    • Author(s)
      阿部達也,丸山 智,山崎 学,Babkair Hamzah,程  クン,朔  敬
    • Organizer
      第25回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      メディアシップ日報ホール(新潟市)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上顎骨病変2014

    • Author(s)
      山崎 学 ,程  クン,丸山 智,阿部達也,西川 敦,高木律男, 西山秀昌,林 孝文,朔  敬
    • Organizer
      第25回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      メディアシップ日報ホール(新潟市)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頬粘膜腫瘍2014

    • Author(s)
      Hamzah Babkair ,程  クン,阿部達也,丸山 智,山崎 学,朔  敬
    • Organizer
      第25回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      メディアシップ日報ホール(新潟市)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] バーチャルスライドを活用した病理組織学実習の導入2014

    • Author(s)
      朔  敬,程  クン,丸山 智,山崎 学,阿部達也,バブカイール ハムザ
    • Organizer
      第25回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      メディアシップ日報ホール(新潟市)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] バーチャルスライドを活用した病理診断・閲覧システムの導入2014

    • Author(s)
      丸山 智,程  クン,山崎 学,阿部達也,バブカイール ハムザ,朔  敬
    • Organizer
      第25回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      メディアシップ日報ホール(新潟市)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Orthokeratinization-related factors in the oral dysplasia squamous cell carcinoma sequences.2014

    • Author(s)
      Abe T, Maruyama S, Yamazaki M, Babkair H, Cheng J, Saku T
    • Organizer
      17th International Congress on Oral Pathology and Medicine
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-05-25 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 角化嚢胞性歯原性腫瘍は咀嚼筋内にも発生する:角化嚢胞の免疫組織化学的鑑別法2014

    • Author(s)
      阿部達也, 丸山 智, 山崎 学, バブカイル ハムザ, 三上俊彦, 新垣 晋, 小林正治, 程  クン, 朔   敬
    • Organizer
      第68回日本口腔科学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞においてMFG-E8は同種死細胞処理たけでなく腫瘍進展にも関与している2014

    • Author(s)
      山崎 学, 程  クン, 丸山 智, 阿部達也, 朔   敬
    • Organizer
      第68回日本口腔科学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腺様嚢胞癌細胞の転移:KGFシングルによる細胞増殖性と遊走性の相反的制御機構2014

    • Author(s)
      丸山 智, 山崎 学, 阿部達也, 程  クン, 朔   敬
    • Organizer
      第68回日本口腔科学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 扁平上皮癌シーケンスにおける正角化関連分子の発現動態2014

    • Author(s)
      阿部達也, 丸山 智, Essa Ahmed, Babkair Hamzah, 山崎 学, 程  クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tight junction molecules claudin 1 and zonula ocludnes 1, in oral sqamous cell caricinoma.2014

    • Author(s)
      Babkair Hamzah, 山崎 学, 阿部達也, Essa Ahmed, 丸山 智, 程  クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞におけるMFG-E8発現の意義:過剰発現細胞系による解析2014

    • Author(s)
      山崎 学, 程  クン, 丸山 智, 阿部達也, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唾液腺多形性腺腫由来SM-AP細胞の増殖は低酸素応答性パールカン生合成に依存している2014

    • Author(s)
      丸山 智, 山崎 学, 阿部達也, Babkair Hamzah, 程  クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Connexin 43 and podoplanin as novel myoepithelial cell markers in salivary gland tumors.2014

    • Author(s)
      Essa Ahmed, 常木雅之, 山崎 学, 丸山 智, 阿部達也, Babkair Hamzah, 程  クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の側方進展界面における細胞死2013

    • Author(s)
      阿部達也,丸山 智,Essa Ahmed, Babkair Hamzah, 山崎 学, 程 クン,朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 口腔扁平苔癬のいわゆるシバット小体における細胞死関連因子の検討2013

    • Author(s)
      阿部達也, 丸山 智, Essa Ahmed, Babkair Hamzah, 程 クン, 朔  敬
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] MFG-E8は口腔扁平上皮癌の進展と死細胞貪食を促進する2013

    • Author(s)
      山崎 学, 程 クン,丸山 智,阿部達也,朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] Stromal macrophages in oral squamous cell carcinoma2013

    • Author(s)
      Essa Ahmed, 山崎 学, 丸山 智,阿部達也,Babkair Hamzah, 程 クン,朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 唾液腺多形性腺腫細胞における低酸素応答性の細胞外基質合成2013

    • Author(s)
      丸山 智, 山崎 学, 阿部達也, 程 クン,朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 下顎窩骨吸収を主徴とした顎関節滑膜性軟骨腫症の1例:初期病像の認識2013

    • Author(s)
      加藤祐介, 小林正治, 三上俊彦, 西山秀昌, 阿部達也, 林 孝文, 朔  敬, 齊藤 力
    • Organizer
      第26回日本顎関節学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍を疑わせた顎関節炎の1例2013

    • Author(s)
      安島久雄, 池田順行, 嵐山貴徳, 齋藤太郎, 荒井良明, 河村篤志, 西山秀昌, 阿部達也, 朔  敬, 高木律男
    • Organizer
      第26回日本顎関節学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 口腔底腫瘍2013

    • Author(s)
      山崎 学, 程 クン,丸山 智, 阿部達也, 池田順行, 永田昌毅, 高木律男, 西山秀昌, 林 孝文, 朔  敬
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 下顎腫瘍2013

    • Author(s)
      丸山 智, 山崎 学, 阿部達也, 櫻井博理, 下山泰明, 程 クン,朔  敬
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 口蓋腫瘍2013

    • Author(s)
      程 クン,丸山 智, 阿部達也, 山崎 学, 朔  敬
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Connexin, a gap junction molecule, in oral carcinoma in-situ and squamous cell carcinoma2013

    • Author(s)
      Essa AA, Yamazaki M, Maruyama S, Abe T, Cheng J, Saku T
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Tight junction molecules in oral carcinoma in-situ and squamous cell carcinoma2013

    • Author(s)
      Babkair H, Cheng J, Maruyama S, Yamazaki M, Abe T, Essa AA, Saku T
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯周嚢胞paradental cystの成立機序に関する臨床病理学的検討2013

    • Author(s)
      朔  敬, 阿部達也, 山崎 学, 程 クン, 丸山 智
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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