Cell competition in lateral invasion fronts of oral carcinoma in-situ
| Project/Area Number |
25861768
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
ABE Tatsuya 新潟大学, 医歯学総合病院, レジデント (70634856)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔上皮内癌 / 口腔扁平上皮癌 / 細胞競合 / 免疫組織化学 / 細胞死 / 口腔異型上皮 |
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| Outline of Final Research Achievements |
Histopathologically, oral carcinoma in-situ (CIS) foci are frequently confronted with non/less malignant lesions including epithelial dysplasia when they invade laterally within the epithelial compartment. In those interfaces, cell competition-like phenomena must occur between CIS cells and less malignant cells. Thus, I have investigated such lateral invasion fronts of oral CIS against normal/dysplasitic epithelia in the tissue section level. There were apoptotic bodies (60%) and eosinophilic hyaline bodies (36%) in SCC/CIS sides of the interfaces. In addition, LC/MS/MS proteomics analysis detected interferon-induced proteins in those interface-adjacent carcinoma cells. These findings suggested carcinoma cells might be losers in cell competition with less malignance cells as winners, and that these cell competitive conditions are induced by cytokines shed from both side cells.
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.2013
Author(s)
Abe T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, Shingaki S, Kobayashi T, Hayashi T, Cheng J, Saku T.
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Journal Title
Hum Pathol.
Volume: 45(1)
Issue: 1
Pages: 110-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Central neurofibroma of the mandible: Report of a case and review of the literature.2013
Author(s)
Metwaly H, Cheng J, Maruyama S, Yamazaki M, Essa A, Abe T, Babkair H, Hoshina H, Takagi R, Hayashi T, Saku T
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 25
Issue: 3
Pages: 294-298
DOI
Related Report
Peer Reviewed
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[Presentation] 腫瘍を疑わせた顎関節炎の1例2013
Author(s)
安島久雄, 池田順行, 嵐山貴徳, 齋藤太郎, 荒井良明, 河村篤志, 西山秀昌, 阿部達也, 朔 敬, 高木律男
Organizer
第26回日本顎関節学会総会・学術大会
Place of Presentation
東京都
Related Report
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[Presentation] 口腔底腫瘍2013
Author(s)
山崎 学, 程 クン，丸山 智, 阿部達也, 池田順行, 永田昌毅, 高木律男, 西山秀昌, 林 孝文, 朔 敬
Organizer
第24回日本臨床口腔病理学会総会・学術大会
Place of Presentation
東京都
Related Report
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[Presentation] 下顎腫瘍2013
Author(s)
丸山 智, 山崎 学, 阿部達也, 櫻井博理, 下山泰明, 程 クン，朔 敬
Organizer
第24回日本臨床口腔病理学会総会・学術大会
Place of Presentation
東京都
Related Report
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