Characterisation of mucosal-type mast cell in Periodontal disease mouse model

• Project/Area Number: 25861781
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nihon University
• Principal Investigator: KOBAYASHI Ryoki 日本大学, 松戸歯学部, 助手(専任扱) (10609085)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔免疫 / 粘膜免疫 / 歯周病 / 歯周病原性細菌 / 肥満細胞

Outline of Final Research Achievements

To clarify the mechanisms of Periodontal diseases which induced by Aggregatibacter actinomycetemcomintas (Aa), we characterised the mucosal-type mast cell (MMC) in the inflamed gingiva of mice with severe alveolar bone loss.

Research Products

• [Presentation] Characterisation of Mast cell in inflamed gingiva in mouse model (2015)
  • Author(s): Kobayashi R., K. Fujihashi and T. Ochiai
  • Organizer: International Congress of Mucosal Immunology 2015
  • Place of Presentation: Maritim Hotel Berlin, Berlin, Germany
  • Year and Date: 2015-07-14 – 2015-07-18
• [Presentation] Foxp3+ Treg cell in Gut-Oral by Probiotic bacterium reduced alveolar bone loss in mouse model. (2014)
  • Author(s): Kobayashi R., T. Hashizume, M. Yamamoto and T. Ochiai.
  • Organizer: Annual Meeting of the molecular biology society of Japan
  • Place of Presentation: パシフィコ横浜、横浜市、神奈川県、日本
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Characterisation of RANKL+CD4+ T cell in inflamed gingiva of periodontal disease mouse model (2014)
  • Author(s): Kobayashi, R. K. Fujihashi, M. Yamamoto and T. Ochiai
  • Organizer: Japanese Conference on Osteoimmunology
  • Place of Presentation: 万国津梁館、名護市、沖縄県、日本
  • Year and Date: 2014-07-01 – 2014-07-04
• [Presentation] Inflamed gingiva drived CD103 negative dendritic cell are differentiate to Foxp3+ T reg cell in Periodontal disease mouse model. (2014)
  • Author(s): Kobayashi R., T. Ochiai, T. Hashizume, K. Fujihashi and M. Yamamoto
  • Organizer: American Association for Immunologists Annual Meeting
  • Place of Presentation: David L. Lawrence Convention Center, Pittsburgh, PA, USA
  • Year and Date: 2014-05-02 – 2014-05-06
• [Presentation] Inflamed gingiva derived CD11c+ Dendritic cell induced Foxp3+ Treg cell (2013)
  • Author(s): Kobayashi R., T. Ochiai, T. Hashizume, K. Fujihashi and M. Yamamoto
  • Organizer: 第４２回 日本免疫学会
  • Place of Presentation: 幕張メッセ （千葉県）