Acquisition of long-term bonding durability due to collagen cross-linked by using the carbodiimide
Project/Area Number |
25861789
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Conservative dentistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 歯質接着レジン / 耐久性 / 接着耐久性 / 象牙質コラーゲン |
Outline of Final Research Achievements |
Bonding system between resin composite and dentin was still developing. Deterioration of the bonding interface had clinical problems such as debonding of restoration and discoloration of bonding interface. The purpose of this study were to reinforce dentin and to acquire constitutivve adhesive durability by crosslinking the collagen. In order to crosslink the collagen, a water soluble carbodiimide was used in this study. It was confirmed that carbodiimide can permeate between collagen molecules. It is expected to contribute to the long-term durability of resin composite restorations.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Inhibition of endogenous human dentin MMPs by Gluma2014
Author(s)
Sabatini C, Scheffel DL, Scheffel RH, Agee KA, Rouch K, Takahashi M, Breschi L, Mazzoni A, Tjäderhane L, Tay FR, Pashley DH.
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Journal Title
Dental Materials
Volume: 7
Issue: 7
Pages: 752-8
DOI
Related Report
Peer Reviewed
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[Journal Article] The importance of size-exclusion characteristics of type I collagen in bonding to dentin matrices.2013
Author(s)
Takahashi M, Nakajima M, Tagami J, Scheffel DL, Carvalho RM, Mazzoni A, Cadenaro M, Tezvergil-Mutluay A, Breschi L, Tjäderhane L, Jang SS, Tay FR, Agee KA, Pashley DH.
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Journal Title
Acta Materialia
Volume: 9
Issue: 12
Pages: 9522-9528
DOI
Related Report
Peer Reviewed
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[Presentation] The size-exclusion characteristics of type I collagen in dentin matrices
Author(s)
Takahashi M, Hosaka K, Nakajima M, Tagami J, Scheffel DLS, Carvalho RM, Mazzoni A, Carrilho MRO, Tezvergil-Mutluay A, Breschi L, Tjaderhane L, Tay FR, Pashley DH
Organizer
IADR-APR
Place of Presentation
Bangkok (Thailand)
Related Report
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[Presentation] Dentin Bond Strength and Mechanical Properties of Two-step Self-etch Adhesives
Author(s)
Sato K, Hosaka K, Chiba A, Thitthaweera S, Takahashi M, Nakajima M, Otsuki M, Tashiro H, Komada W, Miura H, Tagami J
Organizer
IADR-APR
Place of Presentation
Bangkok (Thailand)
Related Report
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