Role of multidrug efflux pumps on Porphyromonas gingivalis biofilm
Project/Area Number |
25861798
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Conservative dentistry
|
Research Institution | Osaka University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | バイオフィルム / 抗菌薬抵抗性 / 薬剤排出ポンプ / ポルフィロモナス ジンジバリス / 抗菌薬感受性 / ポリフィロモナス ジンジバリス |
Outline of Final Research Achievements |
This study showed that Porphyromonas gingivalis, which is a major pathogen in marginal periodontitis and refractory periapical periodontitis, has several genes encoded a putative multidrug efflux pumps. However, two inhibitors of multidrug efflux pump, which were reported to inhibit multidrug efflux pumps in several bacterial species, didn't affect biofilm formation and sensitivity to erythromycin in P gingivalis.
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Report
(4 results)
Research Products
(4 results)