| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
This study showed that Porphyromonas gingivalis, which is a major pathogen in marginal periodontitis and refractory periapical periodontitis, has several genes encoded a putative multidrug efflux pumps. However, two inhibitors of multidrug efflux pump, which were reported to inhibit multidrug efflux pumps in several bacterial species, didn't affect biofilm formation and sensitivity to erythromycin in P gingivalis.
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