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Role of multidrug efflux pumps on Porphyromonas gingivalis biofilm

Research Project

Project/Area Number 25861798
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

Yamaguchi Mikiyo  大阪大学, 歯学研究科(研究院), 助教 (30523089)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオフィルム / 抗菌薬抵抗性 / 薬剤排出ポンプ / ポルフィロモナス ジンジバリス / 抗菌薬感受性 / ポリフィロモナス ジンジバリス
Outline of Final Research Achievements

This study showed that Porphyromonas gingivalis, which is a major pathogen in marginal periodontitis and refractory periapical periodontitis, has several genes encoded a putative multidrug efflux pumps. However, two inhibitors of multidrug efflux pump, which were reported to inhibit multidrug efflux pumps in several bacterial species, didn't affect biofilm formation and sensitivity to erythromycin in P gingivalis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Inhibition of polysaccharide synthesis by the sinR orthologue PGN_0088 is indirectly associated with the penetration of Porphyromonas gingivalis biofilms by macrolide antibiotics.2015

    • Author(s)
      Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Ebisu S, Hayashi M
    • Journal Title

      Microbiology

      Volume: 161 Issue: 2 Pages: 422-429

    • DOI

      10.1099/mic.0.000013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the tea catechin epigallocatechin gallate on Porphyromonas gingivalis biofilms2014

    • Author(s)
      Asahi Y. et al.
    • Journal Title

      Jouranl of Applied Microbiology

      Volume: 116 Issue: 5 Pages: 1164-1171

    • DOI

      10.1111/jam.12458

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Investigation on factors causing refractory periapical periodontitis in general practices

    • Author(s)
      Mikiyo Yamaguchi, Yuichiro Noiri, Yoshihiro Ito, Shungo Komichi, Mikako Hayashi
    • Organizer
      第9回世界歯内療法会議
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] 根尖病変 治癒へ向けた戦略を究める2013

    • Author(s)
      山口幹代、野杁由一郎、
    • Total Pages
      12
    • Publisher
      ヒョーロン・パブリッシャーズ
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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