| Project/Area Number |
25861911
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔学顔面再建外科学 / 骨再生 / 生体内微量元素 / 骨再建 / 幹細胞 |
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| Outline of Final Research Achievements |
In this study, we tried to develop the bone regenerative therapy applied to zinc ion released from zinc modified titanium. To evaluated the stimulative effect of the zinc ion on osteoblast differentiation, we performed alkaline phosphatase staining, real time PCR, alizarin red staining and von Kossa staining. And we confirmed zinc ion released from zinc modified titanium prominently induced osteoblast differentiation. We transplanted the cell cultured for 7 days into subcutaneous and cranial bone defect of experimental animals, however we did not confirmed acceleration of bone formation because of instability of regenerative bone and surgical site infection.
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