Role of HAI-1 and TTSP in Ameloblastoma

• Project/Area Number: 25861961
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Miyazaki
• Principal Investigator: BABA Takashi 宮崎大学, 医学部, 助教 (70626051)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: エナメル上皮腫 / セリンプロテアーゼ

Outline of Final Research Achievements

HAI-1 expression knock-down (KD) in immortalized ameloblastoma cell lines, AM-1 and AM-3, reduced the growth of both lines in vitro. Both HAI-1 KD cell lines also exhiboted significantly enhanced migratory capability.
In 85.7% (12/14) of Ameloblastoma cases, membranous HAI-1immunoreactivity was positive in tumor cells.