The new treatment strategy for lymph node metastasis in oral squamous cell carcinoma - Targeting COX-2 and TAM
| Project/Area Number |
25861978
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / リンパ節転移 / 腫瘍関連マクロファージ / 口腔がん / 口腔扁平上皮癌 / 頸部リンパ節転移 |
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| Outline of Final Research Achievements |
This study aimed to propose new treatment methodology for lymph node metastasis in oral squamous cell carcinoma(OSCC). Especially we focused on Tumor associated macrophage (M2 macrophage) in the tumor microenvironment in OSCC.Our data showed that M2 macrophage strong expression group was significantly related to locally progressive, lymph node metastasis, and prognosis. Moreover, this group showed the tendency that highly expression rate in COX-2 and VEGF-C. In conclusion M2 macrophage in the tumor microenvironment in OSCC might be become the treatment target for prevent the locally progressive, lymph node metastasis.
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Report
(5 results)
Research Products
(7 results)
