Genome-wide association study for abnormal cranio-facial morphology

Research Project

Project/Area Number	25861991
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthodontics/Pediatric dentistry
Research Institution	Hokkaido University
Principal Investigator	Saito Fumio 北海道大学, 大学病院, 助教 (00612889)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	歯学
Outline of Final Research Achievements	five loci (1q32.2, 1p22.3, 6q23.2, 7q11.22 and 15q22.22) were likely to be as novel susceptibility regions of mandibular prognathism. PLXNA2, SSX2IP, TARID, CALN1 and RORA genes were considered as a genetic candidate. PLXNA2 gene is a gene encoding semaphorin co-receptors, and the relations to bone metabolism are reported in semaphorin 3A. It has been reported that SSX2IP gene is related to a Synovium Sarcoma and RORA gene has some kind of functions in bone metabolism. We speculate that these genes may be also associated with mandibular prognathism.

Report

(4 results)