| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, the process of differentiation into osteoblasts of mesenchymal stem cells (MSCs) was examined. We co-transplanted MSCs with hematopoietic stem cells (HSCs) and investigated bone regeneration in mice.
We found that co-culturing the MSCs and HSCs significantly improved MSCs expansion in vitro. More importantly, co-transplantation of MSCs and HSCs markedly increased the plasticity of the MSCs. Our study demonstrated that HSCs markedly accelerated the osteogenesis of MSCs and significantly improved bone formation on the critical size of osseous defect. Therefore, HSCs could have therapeutic value by improving the efficacy of clinical ossification in patients.
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