Exhaustive analysis of nonsyndoromic Oligodoitia in multiple Japanese families
Project/Area Number |
25861996
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
KIDA MIYUKI 北海道大学, 医学(系)研究科(研究院), 客員研究員 (80507442)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 遺伝性非症候性多数歯欠損症 / 網羅的解析 / 遺伝子解析 / 口腔遺伝性疾患 / 多数歯欠損症 |
Outline of Final Research Achievements |
Oligodontia designates the congenital absence of 6 or more permanent teeth, excluding the third molar. I investigated three Japanese families with nonsyndoromic Oligodontia. All affected members in three families were revealed very severe Oligodontia phenotype clinically, number of missing teeth of them were over 10. The early diagnosis and decision on courses of treatment are very important for patients with nonsyndoromic Oligodontia to maintain their quality of life. The aim of the present study revealed the candidate gene of nonsyndoromic Oligodontia and unique SNPs
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning.2015
Author(s)
Otsu M, Yamada M, Nakajima S, Kida M, Maeyama Y, Hatano N, Toita N, Takezaki S, Okura Y, Kobayashi R, Matsumoto Y, Tatsuzawa O, Tsuchida F, Kato S, Kitagawa M, Mineno J, Hershfield MS, Bali P, Candotti F, Onodera M, Kawamura N, Sakiyama Y, Ariga T.
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Journal Title
Journal of Clinical Immunology
Volume: 35(4)
Issue: 4
Pages: 384-398
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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