Association between mild hypoglycemia and mild cognitive impairment in Japanese diabetic patients

• Project/Area Number: 25862144
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical nursing
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Sonoda Nao 滋賀医科大学, 医学部, 助手 (00640153)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 糖尿病患者 / 軽症低血糖 / 認知機能 / MMSE / 生活習慣 / 低血糖 / 低血糖自覚症状

Outline of Final Research Achievements

This study included diabetic patients who were referred to outpatient diabetic clinics.
We assessed the association between mild hypoglycemia and mild cognitive impairment (MCI) in Japanese diabetic patients. Presence or absence of mild hypoglycemia was not associated with MCI, as assessed using the Mini-Mental State Examination (MMSE). Similarly, frequency of mild hypoglycemia was not associated with mild cognitive impairment.Additionally, we assessed the association between lifestyle and MCI in Japanese diabetic patients. Current smoking, especially current smoking for which cumulative lifetime exposure was high, was associated with MCI, as assessed using the MMSE.

Research Products

• [Journal Article] Smoking status is associated with mild cognitive impairment assessed with the mini-mental state examination in Japanese diabetic patients. DOI:10.1007/s13340-016-0256-0. (2016)
  • Author(s): Sonoda N, Morimoto A, Ugi S, Morino K, Sekine O, Nemoto K, Maegawa H, Miyamatsu N.
  • Journal Title: Diabetology International Volume: 1 Issue: 4 Pages: 1-7
  • DOI: 10.1007/s13340-016-0256-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between attentional function and postural instability in Japanese elderly patients with diabetes. (2015)
  • Author(s): Morimoto A, Sonoda N, Ugi S, Morino K, Sekine O, Nemoto K, Ogita M, Tatsumi Y, Murata S, Maegawa H, Miyamatsu N.
  • Journal Title: Diabetology International. Volume: 7 Issue: 1 Pages: 83-88
  • DOI: 10.1007/s13340-015-0231-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between symptoms of bilateral numbness and/or paresthesia in the feet and postural instability in Japanese patients with diabetes (2015)
  • Author(s): Morimoto A, Sonoda N, Ugi S, Morino K, Sekine O, Nemoto K, Ogita M, Tatsumi Y, Murata S, Maegawa H, Miyamatsu N.
  • Journal Title: Diabetology International. Volume: 7 Issue: 1 Pages: 69-76
  • DOI: 10.1007/s13340-015-0214-2
  • NAID: 40020774337
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 滋賀医科大学医学部附属病院外来通院中の糖尿病患者の低血糖実態調査 (2014)
  • Author(s): 園田奈央, 森本明子, 卯木智, 森野勝太郎, 関根理, 前川聡,小林康子, 呉代華容, 森野亜弓,宮松直美
  • Journal Title: 滋賀医大学看護学ジャーナル Volume: 12 Pages: 48-51
  • Peer Reviewed
• [Presentation] 糖尿病患者における喫煙状況と軽度認知機能低下との関連 (2015)
  • Author(s): 園田奈央, 森本明子, 卯木智, 呉代華容, 森野勝太郎, 関根理, 根本憲一, 前川聡, 宮松直美
  • Organizer: 日本循環器予防学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-26 – 2015-06-27
• [Presentation] 糖尿病患者における喫煙状況と軽度認知機能低下との関連 (2015)
  • Author(s): 園田奈央, 森本明子, 卯木智, 呉代華容, 森野勝太郎, 関根理, 根本憲一, 前川聡, 宮松直美．
  • Organizer: 第51回日本循環器予防学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-26
• [Presentation] Predictors for mild and severe hypoglycemia in Japanese outpatients with insulin-treated diabetes: a 6-month follow-up study (2014)
  • Author(s): Sonoda N, Morimoto A, Ugi S, Godai K, Morino K, Sekine O, Nemoto K, Maegawa H, Miyamatsu N.
  • Organizer: 9th Metabolic Syndrome and Atherosclerosis congress
  • Place of Presentation: 京都
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] 一大学病院外来通院中の糖尿病患者の低血糖の実態 (2014)
  • Author(s): 園田奈央, 森本明子, 卯木智, 森野勝太郎, 関根理, 前川聡, 小林康子, 呉代華容, 森野亜弓, 宮松直美
  • Organizer: 第57回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 外来通院中の糖尿病患者の低血糖に関連する要因・疫学会 (2014)
  • Author(s): 園田奈央,森本明子,卯木智,前川聡,小林康子,呉代華容,森野亜弓,宮松直美
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台市