| Project/Area Number |
25870110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
General medical chemistry
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| Research Institution | Tokyo Medical University (2014)
Gunma University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 蛋白質チロシンリン酸化 / チロシンホスファターゼ / 脳高次機能 / チロシン脱リン酸化酵素 / 高次脳機能 |
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| Outline of Final Research Achievements |
The conditional-knockout (cKO) mice lacking Shp2, tyrosine phosphatase, specifically in postmitotic forebrain neurons manifest abnormal behavior, including hyperactivity. In this study, I found that novelty-induced expression of immediate-early genes and activation of extracellular-signal-regulated kinase (Erk) were attenuated in the cerebral cortex and hippocampus of Shp2 cKO mice, suggestive of reduced neuronal activity. The mutant mice also manifested transient impairment of memory formation in the Morris water maze. These results suggest that Shp2 contributes to regulation of Erk activation and synaptic plasticity in postmitotic forebrain neurons and thereby controls locomotor activity and memory formation.
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