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Development of the spectral analytical algorithm for determination of noninvasive blood glucose using t mid-infrared spectroscopy

Research Project

Project/Area Number 25870130
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical systems
Analytical chemistry
Research InstitutionInternational University of Health and Welfare

Principal Investigator

SATO Kenichi  国際医療福祉大学, 保健医療学部, 講師 (90505687)

Co-Investigator(Renkei-kenkyūsha) Nomura Fumio  千葉大学, 医学部附属病院マススペクトロメトリー検査診断学寄付研究部門, 教授 (80164739)
Kitamura Akihide  公益財団法人千葉市産業振興財団, 理事長 (00143248)
Soga Kohei  東京理科大学, 基礎工学部, 教授 (50272399)
Nakaguchi Toshiya  千葉大学, 大学院工学研究科, 教授 (20361412)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords中赤外スペクトル解析 / 血中成分測定 / 血中グルコース測定 / 全血試料無試薬測定 / 非侵襲的血中成分測定 / ヘモグロビンA1C / 中性脂肪 / 総コレステロール / 血糖値(グルコース) / 血糖値
Outline of Final Research Achievements

Determination of blood component (blood test) in clinical laboratory is important for clinical condition grasp, treatment follow-up and evidence of diagnosis. The current standard methods need expensive reagents and devices and take measurement time for around several hours from around ten minutes. Mid-infrared spectroscopy is a simple and reagent-free physicochemical analysis method, and is a potential alternative to more time-consuming and labor-intensive procedures. In this project, we have developed of mid-infrared spectroscopy for blood component determination and examined application to noninvasive testing without drawing blood.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (4 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Similar frequency of paternal uniparental disomy involving chromosome 20q (patUPD20q) in Japanese and Caucasian patients affected by sporadic pseudohypoparathyroidism type Ib (sporPHP1B)2015

    • Author(s)
      Takatani R, Minagawa M, Molinaro A, Reyes M, Kinoshita K, Takatani T, Kazukawa I, Nagatsuma M, Kashimada K, Sato K, Matsushita K, Nomura F, Shimojo N and Jüppner H
    • Journal Title

      Bone

      Volume: 79 Pages: 15-20

    • DOI

      10.1016/j.bone.2015.05.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] "Coexistence of ALK- anaplastic large cell lymphoma and CD4+ T-cell large granular lymphocytic leukemia "2015

    • Author(s)
      Kazuharu Kamachi1, Noriyasu Fukushima, Toshihiko Ando, Ken-ichi Sato, Koichi Ohshima, Masako Yokoo, Takero Shindo, Yasushi Kubota, Kensuke Kojima, Shinya Kimura
    • Journal Title

      Ann Hematol

      Volume: 94 Issue: 3 Pages: 539-540

    • DOI

      10.1007/s00277-014-2176-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中赤外光吸収スペクトル解析による血中成分測定2014

    • Author(s)
      佐藤 謙一
    • Journal Title

      臨床化学

      Volume: 43 Pages: 248-9

    • Related Report
      2014 Research-status Report
  • [Journal Article] 光で血糖値を測定する―中赤外光スペクトル解析による非侵襲的血糖測定2013

    • Author(s)
      佐藤 謙一
    • Journal Title

      化学

      Volume: 68 Pages: 68-69

    • Related Report
      2013 Research-status Report
  • [Presentation] 遺伝学的検査を実践する臨床検査技師の育成2015

    • Author(s)
      佐藤謙一
    • Organizer
      第55回日本臨床化学会年次集会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Simple and easy hepatitis C virus (HCV) genotyping using high resolution melting analysis (HRMA) together with amplicon post HCV viral load determination2014

    • Author(s)
      K Sato, Sakae Itoga, Takayuki Ishige, K Kitamura, F Nomura
    • Organizer
      IFCC 2014
    • Place of Presentation
      Istanbul
    • Related Report
      2013 Research-status Report
  • [Presentation] 中赤外光吸収スペクトル解析による血中成分測定~無試薬で簡便なChylomicron-Triglyceride(CM-TG)とVery low density lipoprotein-Triglyceride(VLDL-TG)測定~2013

    • Author(s)
      佐藤謙一、清宮正徳、澤部祐司、野村文夫
    • Organizer
      第62回日本医学検査学会
    • Place of Presentation
      高松
    • Related Report
      2013 Research-status Report
  • [Presentation] Highly sensitive detection of EGFR mutations using Bronchoscopic Ultra-Micro Sampling in patients with Non-Small Cell Lung Cancer (NSCLC)2013

    • Author(s)
      K. Sato, S. Itoga, Y. Sakairi, T. Ishige, K. Matsushita, I. Yoshino, F. Nomura
    • Organizer
      2013 AACC annual meeting
    • Place of Presentation
      Houston
    • Related Report
      2013 Research-status Report
  • [Book] 遺伝子検査技術―遺伝子分析科学認定士テキスト2016

    • Author(s)
      佐藤謙一
    • Total Pages
      2
    • Publisher
      宇宙堂八木書店
    • Related Report
      2015 Annual Research Report
  • [Remarks] 教員紹介

    • URL

      http://fukuoka.iuhw.ac.jp/faculty/mt-teacher.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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