| Project/Area Number |
25870373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
Tumor biology
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| Research Institution | Kyoto University |
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Principal Investigator |
OKUDA HIROSHI 京都大学, 医学(系)研究科(研究院), 助教 (10629215)
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| Research Collaborator |
YOKOYAMA Akihiko 京都大学, 大学院医学研究科, 特定准教授 (10506710)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 白血病 / 発がん / MLL / AF4 / 転写 / がん |
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| Outline of Final Research Achievements |
Chromosomal translocation generates MLL chimeras. MLL chimeras are fused with a component of AF4 transcriptional co-activator complex, constitutively activate the downstream genes to immortalize hematopoietic progenitor cells. However, it is not yet known how AF4 complex activates transcription of the downstream genes to cause leukemia. Here, we identified co-factors that bind to the AF4 complex, and characterized the mechanism of transcriptional activation by AF4 complex through the function of the co-factors. We also succeeded to attenuate growth of leukemic cells by inhibition of the co-factor.
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