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Development of tissue viscoelasticity imaging technology based on high frame rate ultrasound imaging method

Research Project

Project/Area Number 25870376
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical systems
Biomedical engineering/Biomaterial science and engineering
Research InstitutionKyoto University

Principal Investigator

YAMAKAWA Makoto  京都大学, 先端医工学研究ユニット, 特定准教授 (60344876)

Research Collaborator SHIINA Tsuyoshi  京都大学, 医学研究科, 教授 (40192603)
KONDO Kengo  京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (50649233)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords超音波 / 組織粘弾性イメージング / 高フレームレート計測 / ひずみ分布 / せん断波
Outline of Final Research Achievements

We proposed the tissue viscoelasticity imaging method which can measure tissue viscoelasticity quantitatively and can evaluate the frequency characteristic of tissue viscoelasticity. In this method, we vibrate a tissue with an ultrasound probe, and we measure the tissue strain distribution and strain distribution of reference area using high frame rate ultrasound imaging method. We also proposed the tissue elasticity imaging method using shear wave generated by probe vibration. We evaluated the validity, accuracy and limit of the proposed methods by simulations and phantom experiments. Furthermore, we developed the tissue viscoelasticity imaging system based on the proposed methods.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Invited: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Principle of Ultrasound Elastography Based on Shear Wave Propagation2014

    • Author(s)
      山川 誠
    • Journal Title

      Medical Imaging Technology

      Volume: 32 Issue: 2 Pages: 75-80

    • DOI

      10.11409/mit.32.75

    • NAID

      130004554961

    • ISSN
      0288-450X, 2185-3193
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Shear wave elasticity imaging using inverse filtering and multiple-point shear wave generation2014

    • Author(s)
      Kitazaki, T ; Shiina, T. ; Kondo, K. ; Yamakawa, M
    • Journal Title

      2014 IEEE International Ultrasonics Symposium

      Volume: 1 Pages: 1121-1123

    • DOI

      10.1109/ultsym.2014.0275

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coded Excitation Scheme for Acoustic Radiation Push Pulse Compression2013

    • Author(s)
      Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina
    • Journal Title

      Proc. of 2013 IEEE Ultrasonics Symposium

      Volume: 1 Pages: 341-343

    • DOI

      10.1109/ultsym.2013.0088

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Viscoelasticity Phantom and Its Quantitative Assessment Methods with Shear Wave2014

    • Author(s)
      五明美香子, 近藤健悟, 山川誠, 椎名毅
    • Organizer
      第35回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      明治大学
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estimation of Tissue Viscoelasticity Using Inverse Filter and Multiple-Point Shear Wave Generation2014

    • Author(s)
      T. Kitazaki, K. Kondo, M. Yamakawa, T. Shiina
    • Organizer
      the Thirteenth International Tissue Elasticity Conference
    • Place of Presentation
      Utah, USA
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 受動励振による組織粘弾性評価の実験的検討2014

    • Author(s)
      小江啓介, 近藤健悟, 山川誠, 椎名毅
    • Organizer
      日本超音波医学会 平成26年度第3回基礎技術研究会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超音波プローブ加振による組織粘弾性イメージング2014

    • Author(s)
      山川誠, 椎名毅
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 剪断波による組織粘性・弾性分布の画像化の検討2014

    • Author(s)
      五明美香子, 近藤健悟, 山川誠, 椎名毅
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] プローブ加振によるせん断波を用いた2-D Transient elastographyの基礎検討2014

    • Author(s)
      山川誠, 椎名毅
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mapping Viscoelastic Properties Using Acoustic Radiation Force

    • Author(s)
      Mikako Gomyo, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina
    • Organizer
      12th International Tissue Elasticity Conference
    • Place of Presentation
      リングフィールド, イギリス
    • Related Report
      2013 Research-status Report
  • [Presentation] 3次元血管モデルにおけるせん断波の方向依存性

    • Author(s)
      張俊根, 近藤健悟, 山川誠, 椎名毅
    • Organizer
      第34回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      同志社大学
    • Related Report
      2013 Research-status Report
  • [Remarks] 京都大学大学院医学研究科人間健康科学系専攻情報理工医療学講座医療画像情報システム研究室

    • URL

      http://shiina-lab.hs.med.kyoto-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 超音波診断装置2014

    • Inventor(s)
      山川誠, 椎名毅, 大坂卓司, 三竹毅
    • Industrial Property Rights Holder
      山川誠, 椎名毅, 大坂卓司, 三竹毅
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-09
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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