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Classification and characterization of a novel basal-like breast cancer group.

Research Project

Project/Area Number 25870384
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Tumor diagnostics
Research InstitutionKyoto University

Principal Investigator

ITOU Junji  京都大学, 医学(系)研究科(研究院), 特定助教 (10638844)

Research Collaborator MATSUMOTO Yoshiaki  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌細胞 / 転写因子 / 増殖能 / 運動能 / Basal-like乳癌 / 幹細胞転写因子 / 細胞増殖 / 細胞運動 / 細胞 / 移動 / 増殖 / 幹細胞 / 細胞生物学 / 分子生物学 / 遺伝学
Outline of Final Research Achievements

Understanding molecular characteristics of cancer will facilitate cancer therapy. This study found a novel basal-like breast cancer cell group, the malignancy of which is regulated by a transcription factor SALL4. Knockdown experiments for SALL4 revealed that SALL4 maintains cell proliferation. In addition, SALL4 increases motility via suppression of cell-cell adhesion. These observations contribute to our understanding of basal-like breast cancer.
To further study for basal-like breast cancer cells, this study established a novel fluorescent protein-based proliferation assay. This assay utilizes photoconvertible fluorescent protein, Kaede, for pulse-labeling. In our observation, there always are few non- or slow-cycling cells in basal-like breast cancer cell lines. This technique will be a useful tool for cancer researches and anti-cancer drug development.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] An optical labeling-based proliferation assay system reveals the paracrine effect of interleukin-6 in breast cancer.2015

    • Author(s)
      Itou J, Tanaka S, Sato F, Akiyama R, Kawakami Y, Toi M.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1853 Issue: 1 Pages: 27-40

    • DOI

      10.1016/j.bbamcr.2014.10.004

    • NAID

      120005512254

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Function of the Developmental Transcription Factor SALL4 in Cancer2014

    • Author(s)
      Junji Itou, Masakazu Toi
    • Journal Title

      Journal of Carcinogenesis and Mutagenesis

      Volume: 5 Issue: 02 Pages: 159-159

    • DOI

      10.4172/2157-2518.1000159

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer2013

    • Author(s)
      Junji Itou, Yoshiaki Matsumoto, Kiyotsugu Yoshikawa, Masakazu Toi
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 18 Pages: 3115-3121

    • DOI

      10.1016/j.febslet.2013.07.049

    • NAID

      120005512255

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Activation of motility by SALL4-regulated integrin expression in basal-like breast cancer2015

    • Author(s)
      Junji Itou, Sunao Tanaka, Fumiaki Sato, Masakazu Toi
    • Organizer
      EMBL Symposia, Frontiers in Stem Cells & Cancer
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2015-03-29 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of slow-cycling cancer stem cell via an optical labeling-based proliferation assay system in basal-like breast cancer2015

    • Author(s)
      Sunao Tanaka, Junji Itou, Wenzhao Li, Fumiaki Sato, Masakazu Toi
    • Organizer
      EMBL Symposia, Frontiers in Stem Cells & Cancer
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2015-03-29 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳癌において SALL4 が制御する遺伝子群の解析2014

    • Author(s)
      伊東潤二、松本純明、吉川清次、戸井雅和
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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