Development of phospholamban aptamer as a novel therapeutic tool for treatment of heart failure
| Project/Area Number |
25870470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
Applied pharmacology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SAKAI Hiroki 山口大学, 医学(系)研究科(研究院), 助教 (40464367)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ホスホランバン / アプタマー / 心不全治療薬 / 細胞膜透過性ペプチド / 核酸アプタマー |
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| Outline of Final Research Achievements |
We tried to develop phospholamban aptamer as a novel therapeutic tool for treatment of heart failure. We conjugated the phospholamban RNA aptamer with a cell-penetrating peptide, the modified TAT peptide. This cell-penetrating phospholamban aptamer enhanced contraction/relaxation of isolated adult rat cardiomyocytes as well as corresponding Ca2+ transients. In the mouse heart failure model, the cell-penetrating phospholamban aptamer improved cardiac functions some mice. These results suggested that the cell-panetrating phospholamban aptamer is a potential therapeutic tool for treatment of heart failure.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes.2014
Author(s)
Sakai, H., Ikeda, Y., Honda, T., Tanaka, Y., Shiraishi, K., and Inui, M.
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Journal Title
J. Mol. Cell. Cardiol.
Volume: 76
Pages: 177-185
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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