Prion protein overexpress induces on autophagy mechanism explication.

Research Project

Project/Area Number	25870474
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pathological medical chemistry Neurology
Research Institution	The University of Tokushima
Principal Investigator	YANO Masashi 徳島大学, 疾患酵素学研究センター, 技術員 (10531858)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	プリオン / オートファジー
Outline of Final Research Achievements	Prion is the disease to which neurodegeneration death happens by surplus accumulation of prion protein. The mechanism of this nerve cell death is unclear, but participation of apoptosis through autophagy is advocated. In this study, I worked on mechanism of activation of the autophagy which happens by the thing which makes a HEK293T cells protein overexpress. It's analyzed using a prion model mice whether this mechanism by HEK293T cells participates in nerve cell death of prion.