Generation of a complihensive predictor for neoadjuvant endocrine therapy responsiveness in breast cancer

Research Project

Project/Area Number	25870539
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor diagnostics General surgery
Research Institution	Kumamoto University
Principal Investigator	YAMAMOTO-IBUSUKI Mutsuko 熊本大学, 大学院生命科学研究部, 助教 (30448526)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	治療効果予測因子 / 術前ホルモン療法 / 内分泌療法感受性
Outline of Final Research Achievements	To evaluate the responsiveness for endocrine therapy of breast cancer, we speculated that there are some systemic variables in intrinsic breast cancer subtype in ER positive breast tumor and growth factor signaling pathway activation. We indicated a specific pattern of DNA copy number of tumor consisted with 11 locus was correlated with poor responsiveness to neoadjuvant endocrine therapy(p=0.034). And more, among PI3K-signalung pathway, phospho-Akt either showed significant correlation with poor responsiveness by IHC investigation（p=0.005）.