Generation of a complihensive predictor for neoadjuvant endocrine therapy responsiveness in breast cancer
| Project/Area Number |
25870539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 治療効果予測因子 / 術前ホルモン療法 / 内分泌療法感受性 |
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| Outline of Final Research Achievements |
To evaluate the responsiveness for endocrine therapy of breast cancer, we speculated that there are some systemic variables in intrinsic breast cancer subtype in ER positive breast tumor and growth factor signaling pathway activation. We indicated a specific pattern of DNA copy number of tumor consisted with 11 locus was correlated with poor responsiveness to neoadjuvant endocrine therapy(p=0.034). And more, among PI3K-signalung pathway, phospho-Akt either showed significant correlation with poor responsiveness by IHC investigation（p=0.005）.
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Report
(3 results)
Research Products
(1 results)
