Preparation of Folate-appended methylated cyclodextrin polyrotaxanes as novel biomaterials
| Project/Area Number |
25870542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Higashi Taishi 熊本大学, 大学院生命科学研究部, 助教 (20613409)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | シクロデキストリン / ポリ擬ロタキサン / ポリロタキサン / ワンポット / 超分子 / one-pot / 医薬品候補化合物 / 分子ネックレス / がん / 葉酸 |
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| Outline of Final Research Achievements |
In this study, we prepared cyclodextrin molecular necklaces through one-pot synthesis. In general, multi-step synthesis is required to prepare the cyclodextrin molecular necklaces. 2, 6-Di-O-methyl cyclodextrins, one of the cyclodextrin derivatives, formed molecular necklaces at high temperature with high yield in one-pot. Currently, we perform the applied research of the molecular necklaces.
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Report
(4 results)
Research Products
(10 results)
