| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
The ER is the organelle in which proteins form their functional tertiary structure. Dysfunction of the ER leads to the accumulation of misfolded proteins in the ER. Cells possess ER quality control systems to remove these proteins and thereby survive. On the other hand, tumor cells are challenged by microenvironments such as hypoxia and hypoglycemia, which lead to the induction of ER stress. It is well known that ER stress-induced survival signaling is activated during tumor cell growth. However, the molecular mechanism underlying this process remains unclear. Is this project, we focused on oral cancer in which significance of ER stress signaling has never been evaluated and aimed at therapeutic approaches.
Our results from the experiments using anticancer agent which induces ER stress-mediated cell death revealed that ER stress is involved in cancer.
|
