Development of subtyping cytomegalovirus using cell tropism and pathogenesis
| Project/Area Number |
25870580
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
Pathological medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Ikuta Kazufumi 福島県立医科大学, 医学部, 講師 (60512184)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 先天感染 / サイトメガロウイルス / 単純ヘルペスウイルス / 組換えウイルス |
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| Outline of Final Research Achievements |
We performed a basic research aimed to develop the subtyping of cytomegalovirus (CMV) based on its pathogenicity related tropism. Multiple trials were performed by using two herpes simplex virus type 1 strains with difference of sorivudine (BVara-U) sensitivity. Sensorineural hearing loss (SNHL) is often observed in children with congenital CMV infection. We analyzed the CMV infecting site in ears by establishing mouse model of CMV-induced SNHL.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Cytomegalovirus (CMV) glycoprotein H-based serological analysis in Japanese healthy pregnant women, and in neonates with congenital CMV infection and their mothers.2013
Author(s)
14. Ikuta K, Minematsu T, Inoue N, Kubo T, Asano K, Ishibashi K, Imamura T, Nakai H, Yoshikawa T, Moriuchi H, Fujiwara S, Koyano S, Suzutani T
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Journal Title
J Clin Virol
Volume: 58
Issue: 2
Pages: 474-478
DOI
Related Report
Peer Reviewed
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[Presentation] Restricted infection of murine cytomegalovirus (MCMV) in neonatal mice with MCMV-induced sensorineural hearing loss.2015
Author(s)
Ikuta K., Ogawa H., Hashimoto H., Okano W., Tani A., Sato E., Kosugi I., Kobayashi T., Omori K., Suzutani T
Organizer
5th International Congenital CMV Conference, 15th International CMV/Beta herpesvirus Workshop.
Place of Presentation
ブリスベン
Year and Date
2015-04-20
Related Report
Int'l Joint Research
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